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    Mtkl Mtk-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 12798466, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mtklprovided by FlyBase
    Official Full Name
    Mtk-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262881
    Locus tag
    Dmel_CG43236
    See related
    AllianceGenome:FB:FBgn0262881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG43236; Dmel\CG43236
    Summary
    Involved in response to wounding. Located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Mtkl in Genome Data Viewer
    Location:
    51B7-51B7; 2-72 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14638538..14638935)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10526043..10526440)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene U snoRNA host gene 5 Neighboring gene ncRNA Neighboring gene beta Hydroxy acid dehydrogenase 2 Neighboring gene long non-coding RNA:CR42715 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A single-cell survey of Drosophila blood. Tattikota SG, et al. Elife, 2020 May 12. PMID 32396065, Free PMC Article
    2. Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD. Lee S, et al. Neuron, 2023 May 3. PMID 36931278, Free PMC Article
    3. Temporal Exposure to Bt Insecticide Causes Oxidative Stress in Larval Midgut Tissue. Muita BK, et al. Toxins (Basel), 2023 May 7. PMID 37235357, Free PMC Article
    4. Bacterial peptidoglycan serves as a critical modulator of the gut-immune-brain axis in Drosophila. Fioriti F, et al. Brain Behav Immun, 2024 Jul. PMID 38710338
    5. An anti-inflammatory transcriptional cascade conserved from flies to humans. Pavlidaki A, et al. Cell Rep, 2022 Oct 18. PMID 36261018

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mtk-like
    Names
    CG43236-PA
    CG43236-PB
    Mtkl-PA
    Mtkl-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14638538..14638935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299494.1 → NP_001286423.1  Mtk-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286423.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF43, C0PV06

    2. NM_001259393.2 → NP_001246322.1  Mtk-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246322.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF43, C0PV06
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF43 A0A0B4LF43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials