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    Dnah10 dynein, axonemal, heavy chain 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117252, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dnah10provided by RGD
    Official Full Name
    dynein, axonemal, heavy chain 10provided by RGD
    Primary source
    RGD:619988
    See related
    EnsemblRapid:ENSRNOG00000052704 AllianceGenome:RGD:619988
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and dynein intermediate chain binding activity. Predicted to be involved in cell projection organization; microtubule-based movement; and proton transmembrane transport. Predicted to be located in axoneme; microtubule; and motile cilium. Predicted to be part of dynein complex. Human ortholog(s) of this gene implicated in spermatogenic failure 56. Orthologous to human DNAH10 (dynein axonemal heavy chain 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 39.6), Testes (RPKM 39.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnah10 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    80
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37484444..37607810, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (31823451..31946857, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37237482..37365258, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 664 Neighboring gene ribosomal protein L27 like 5 Neighboring gene coiled-coil domain containing 92 Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene uncharacterized LOC120095966 Neighboring gene ATPase H+ transporting V0 subunit a2 Neighboring gene uncharacterized LOC134481292 Neighboring gene tectonic family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein heavy chain 10, axonemal; dynein axonemal heavy chain 10
    Names
    dynein, axonemal, heavy polypeptide 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      37484444..37607810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090119.2 → XP_038946047.1  dynein axonemal heavy chain 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A269
      Conserved Domains (6) summary
      COG5245
      Location:1615 → 4233
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:308 → 878
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1374 → 1779
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1914 → 2240
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2893 → 3152
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:4290 → 4588
      Dynein_C; Dynein heavy chain C-terminal domain

    2. XM_008769272.4 → XP_008767494.2  dynein axonemal heavy chain 10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A269, A0A8I6GMJ7
      Related
      ENSRNOP00000084529.2, ENSRNOT00000106066.2
      Conserved Domains (6) summary
      COG5245
      Location:1616 → 4234
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:309 → 879
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1375 → 1780
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1915 → 2241
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2894 → 3153
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:4291 → 4589
      Dynein_C; Dynein heavy chain C-terminal domain

    3. XM_039090122.2 → XP_038946050.1  dynein axonemal heavy chain 10 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A269
      Conserved Domains (6) summary
      COG5245
      Location:1086 → 3704
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:1 → 349
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:845 → 1250
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1385 → 1711
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2364 → 2623
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:3761 → 4059
      Dynein_C; Dynein heavy chain C-terminal domain

    4. XM_039090123.2 → XP_038946051.1  dynein axonemal heavy chain 10 isoform X4

      Conserved Domains (5) summary
      COG5245
      Location:374 → 2992
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:133 → 538
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:673 → 999
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:1652 → 1911
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:3049 → 3347
      Dynein_C; Dynein heavy chain C-terminal domain

    RNA

    1. XR_005491954.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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