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    Nmrk2 nicotinamide riboside kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100912521, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nmrk2provided by RGD
    Official Full Name
    nicotinamide riboside kinase 2provided by RGD
    Primary source
    RGD:6486791
    See related
    EnsemblRapid:ENSRNOG00000042897 AllianceGenome:RGD:6486791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Predicted to act upstream of or within negative regulation of myoblast differentiation. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 420.3), Heart (RPKM 176.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nmrk2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9165567..9168638)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8514855..8517916)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11382966..11386170)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene zinc finger RNA binding protein 2 Neighboring gene ATCAY kinesin light chain interacting caytaxin Neighboring gene uncharacterized LOC134479805 Neighboring gene death-associated protein kinase 3 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Bieganowski P, et al. Cell, 2004 May 14. PMID 15137942
    2. A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. Li J, et al. J Cell Biol, 1999 Dec 27. PMID 10613898, Free PMC Article
    3. Nicotinamide riboside kinase structures reveal new pathways to NAD+. Tempel W, et al. PLoS Biol, 2007 Oct 2. PMID 17914902, Free PMC Article
    4. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Houtkooper RH, et al. Endocr Rev, 2010 Apr. PMID 20007326, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribosylnicotinamide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosylnicotinamide kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosylnicotinate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nicotinamide riboside kinase 2
    XP_003750325.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432213.1 → NP_001419142.1  nicotinamide riboside kinase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K8B4, D3ZBU8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9165567..9168638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003750277.6 → XP_003750325.2  nicotinamide riboside kinase 2

      UniProtKB/TrEMBL
      D3ZBU8
      Related
      ENSRNOP00000062386.4, ENSRNOT00000066348.5
      Conserved Domains (1) summary
      cd02024
      Location:38 → 197
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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