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    dock10 dedicator of cytokinesis 10 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100127561, updated on 4-Nov-2024

    Summary

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    Official Symbol
    dock10provided by Xenbase
    Official Full Name
    dedicator of cytokinesis 10provided by Xenbase
    Primary source
    Xenbase:XB-GENE-1004971
    See related
    Ensembl:ENSXETG00000005142 AllianceGenome:Xenbase:XB-GENE-1004971
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    ziz3; drip2; nbla10300
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Orthologous to human DOCK10 (dedicator of cytokinesis 10). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dock10 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (119368321..119524728)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (115944202..116067810)

    Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC116410984 Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 Neighboring gene putative coiled-coil domain-containing protein 195 Neighboring gene guanylate cyclase 1, soluble, beta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      119368321..119524728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031902394.1 → XP_031758254.1  dedicator of cytokinesis protein 10 isoform X5

      UniProtKB/TrEMBL
      A0A803J8H7, A0A8J1JK51
      Related
      ENSXETP00000104180.1, ENSXETT00000114545.1

    2. XM_031902392.1 → XP_031758252.1  dedicator of cytokinesis protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A8J1JK52, F7BRY3
      Conserved Domains (4) summary
      cd08697
      Location:687 → 875
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1700 → 2147
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:201 → 316
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)

    3. XM_031902390.1 → XP_031758250.1  dedicator of cytokinesis protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A8J1JMJ6, F7BRY3
      Conserved Domains (4) summary
      cd08697
      Location:687 → 875
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1709 → 2156
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:201 → 316
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)

    4. XM_031902396.1 → XP_031758256.1  dedicator of cytokinesis protein 10 isoform X6

      UniProtKB/TrEMBL
      A0A8J1JNS5, F7BRY3
      Conserved Domains (4) summary
      cd08697
      Location:687 → 875
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:201 → 316
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1709 → 2123
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    5. XM_031902391.1 → XP_031758251.1  dedicator of cytokinesis protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A8J1JNS0, F7BRY3
      Related
      ENSXETP00000011185.5, ENSXETT00000011185.5
      Conserved Domains (4) summary
      cd08697
      Location:687 → 875
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1709 → 2154
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:201 → 316
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)

    6. XM_031902397.1 → XP_031758257.1  dedicator of cytokinesis protein 10 isoform X7

      UniProtKB/TrEMBL
      A0A8J1JK56, F7BRY3
      Conserved Domains (4) summary
      cd08697
      Location:687 → 875
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:201 → 316
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1709 → 2121
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    7. XM_031902393.1 → XP_031758253.1  dedicator of cytokinesis protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A8J1JK48, F7BRZ1
      Related
      ENSXETP00000011184.6, ENSXETT00000011184.6
      Conserved Domains (4) summary
      cd08697
      Location:669 → 857
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1691 → 2138
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:183 → 298
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:40 → 150
      DUF3398; Domain of unknown function (DUF3398)
    Nucleotide Protein Strain
    Heading Accession and Version

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