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    sulf1 sulfatase 1 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100038259, updated on 4-Nov-2024

    Summary

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    Official Symbol
    sulf1provided by Xenbase
    Official Full Name
    sulfatase 1provided by Xenbase
    Primary source
    Xenbase:XB-GENE-966419
    See related
    Ensembl:ENSXETG00000015231 AllianceGenome:Xenbase:XB-GENE-966419
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    sulf-1; XtSulf1; hsulf-1; XtSulf-1
    Summary
    Predicted to enable N-acetylglucosamine-6-sulfatase activity; arylsulfatase activity; and calcium ion binding activity. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; regulation of signal transduction; and skeletal system development. Predicted to be located in several cellular components, including Golgi stack; cell surface; and endoplasmic reticulum. Is expressed in anatomical system; mesenchyme; pharyngeal arch; and primary germ layer. Orthologous to human SULF1 (sulfatase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sulf1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 6 NC_030682.2 (119911586..119993145)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 6 NC_030682.1 (105053554..105135540)

    Chromosome 6 - NC_030682.2Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Neighboring gene chromosome 6 C8orf34 homolog Neighboring gene solute carrier organic anion transporter family member 5A1 Neighboring gene PR domain 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sulf1 influences the Shh morphogen gradient during the dorsal ventral patterning of the neural tube in Xenopus tropicalis. Ramsbottom SA, et al. Dev Biol, 2014 Jul 15. PMID 24768893
    2. Extracellular regulation of developmental cell signaling by XtSulf1. Freeman SD, et al. Dev Biol, 2008 Aug 15. PMID 18617162
    3. Neural crest migration requires the activity of the extracellular sulphatases XtSulf1 and XtSulf2. Guiral EC, et al. Dev Biol, 2010 May 15. PMID 20206618
    4. Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling. Fellgett SW, et al. J Cell Sci, 2015 Apr 1. PMID 25681501, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sulf1 enhances the ability of Wnt11b to activate canonical and non-canonical Wnt signaling.
      Title: Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling.
    2. Sulf1 is required for normal specification of neural progenitors in the ventral neural tube, a process known to require a gradient of Shh activity.
      Title: Sulf1 influences the Shh morphogen gradient during the dorsal ventral patterning of the neural tube in Xenopus tropicalis.
    3. Study demonstrates that endogenous XtSulf1 and XtSulf2 play an important role during cranial neural crest cell migration in vivo.
      Title: Neural crest migration requires the activity of the extracellular sulphatases XtSulf1 and XtSulf2.
    4. while XtSulf1 can enhance the axis-inducing activity of Wnt11, XtSulf1 acts during embryogenesis to restrict BMP and FGF signaling.
      Title: Extracellular regulation of developmental cell signaling by XtSulf1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arylsulfatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood circulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bone development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cartilage development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chondrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epithelial structure maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within esophagus smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glial cell-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heparan sulfate proteoglycan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innervation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kidney development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuromast deposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of myotome development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vasculature development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    extracellular sulfatase Sulf-1
    Names
    extracellular 6-O-endosulfatase
    NP_001090848.1
    XP_012819608.1
    XP_012819609.1
    XP_012819610.1
    XP_012819611.1
    XP_012819612.1
    XP_017949996.1
    XP_031759014.1
    XP_031759015.1
    XP_031759016.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097379.1 → NP_001090848.1  extracellular sulfatase Sulf-1 precursor

      See identical proteins and their annotated locations for NP_001090848.1

      Status: PROVISIONAL

      Source sequence(s)
      EF409382
      UniProtKB/TrEMBL
      A0A6I8RI34, A3FMN5
      Related
      ENSXETP00000058503.3, ENSXETT00000065243.3
      Conserved Domains (4) summary
      COG3119
      Location:41 → 386
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      pfam12548
      Location:540 → 690
      DUF3740; Sulfatase protein
      cd16147
      Location:41 → 383
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:781 → 830
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030682.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      119911586..119993145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012964156.3 → XP_012819610.1  extracellular sulfatase Sulf-1 isoform X4

      See identical proteins and their annotated locations for XP_012819610.1

      UniProtKB/TrEMBL
      A0A6I8QMY5, A0A6I8SYV5
      Conserved Domains (3) summary
      cd16147
      Location:41 → 383
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533 → 690
      DUF3740; Sulfatase protein
      cl23718
      Location:781 → 830
      ALP_like; alkaline phosphatases and sulfatases

    2. XM_012964155.3 → XP_012819609.1  extracellular sulfatase Sulf-1 isoform X3

      UniProtKB/TrEMBL
      A0A6I8QMY5, A0A8J0SPY9
      Conserved Domains (4) summary
      COG3119
      Location:60 → 405
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      pfam12548
      Location:559 → 709
      DUF3740; Sulfatase protein
      cd16147
      Location:60 → 402
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:800 → 849
      ALP_like; alkaline phosphatases and sulfatases

    3. XM_031903155.1 → XP_031759015.1  extracellular sulfatase Sulf-1 isoform X4

      UniProtKB/TrEMBL
      A0A6I8QMY5, A0A6I8SYV5
      Related
      ENSXETP00000069877.2, ENSXETT00000073825.2
      Conserved Domains (3) summary
      cd16147
      Location:41 → 383
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533 → 690
      DUF3740; Sulfatase protein
      cl23718
      Location:781 → 830
      ALP_like; alkaline phosphatases and sulfatases

    4. XM_012964158.3 → XP_012819612.1  extracellular sulfatase Sulf-1 isoform X4

      See identical proteins and their annotated locations for XP_012819612.1

      UniProtKB/TrEMBL
      A0A6I8QMY5, A0A6I8SYV5
      Conserved Domains (3) summary
      cd16147
      Location:41 → 383
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533 → 690
      DUF3740; Sulfatase protein
      cl23718
      Location:781 → 830
      ALP_like; alkaline phosphatases and sulfatases

    5. XM_012964157.3 → XP_012819611.1  extracellular sulfatase Sulf-1 isoform X4

      See identical proteins and their annotated locations for XP_012819611.1

      UniProtKB/TrEMBL
      A0A6I8QMY5, A0A6I8SYV5
      Related
      ENSXETP00000099005.2, ENSXETT00000071938.2
      Conserved Domains (3) summary
      cd16147
      Location:41 → 383
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533 → 690
      DUF3740; Sulfatase protein
      cl23718
      Location:781 → 830
      ALP_like; alkaline phosphatases and sulfatases

    6. XM_031903154.1 → XP_031759014.1  extracellular sulfatase Sulf-1 isoform X2

      UniProtKB/TrEMBL
      A0A6I8QMY5, A0A8J1JMB2
      Conserved Domains (3) summary
      cd16147
      Location:83 → 425
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:573 → 712
      DUF3740; Sulfatase protein
      cl23718
      Location:803 → 852
      ALP_like; alkaline phosphatases and sulfatases

    7. XM_012964154.3 → XP_012819608.1  extracellular sulfatase Sulf-1 isoform X1

      UniProtKB/TrEMBL
      A0A6I8QMY5, A0A6I8SMA3
      Related
      ENSXETP00000093253.2, ENSXETT00000077516.2
      Conserved Domains (3) summary
      cd16147
      Location:83 → 425
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:575 → 735
      DUF3740; Sulfatase protein
      cl23718
      Location:823 → 872
      ALP_like; alkaline phosphatases and sulfatases

    8. XM_031903156.1 → XP_031759016.1  extracellular sulfatase Sulf-1 isoform X6

      UniProtKB/TrEMBL
      A0A6I8RI34, A0A8J1JR04
      Related
      ENSXETP00000065281.2, ENSXETT00000082627.2
      Conserved Domains (3) summary
      cd16147
      Location:83 → 425
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:575 → 732
      DUF3740; Sulfatase protein
      cl23718
      Location:823 → 872
      ALP_like; alkaline phosphatases and sulfatases

    9. XM_018094507.2 → XP_017949996.1  extracellular sulfatase Sulf-1 isoform X5

      UniProtKB/TrEMBL
      A0A6I8QMY5, A0A8J0SUB5
    Nucleotide Protein Strain
    Heading Accession and Version

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