sptan1 spectrin, alpha, non-erythrocytic 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: sptan1provided by Xenbase
Official Full Name: spectrin, alpha, non-erythrocytic 1provided by Xenbase
Primary source: Xenbase:XB-GENE-986854
See related: Ensembl:ENSXETG00000012869 AllianceGenome:Xenbase:XB-GENE-986854
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: neas; sptan1-a; sptan1-b
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within actin filament capping. Predicted to be located in cell cortex and cytoskeleton. Predicted to be active in several cellular components, including cell junction; cortical actin cytoskeleton; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 11 and developmental and epileptic encephalopathy 5. Orthologous to human SPTAN1 (spectrin alpha, non-erythrocytic 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 8

Exon count:: 57

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (22655947..22694414, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (4217751..4256346)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament capping	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intracellular non-membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: spectrin alpha chain, non-erythrocytic 1

Names: (alpha)ii-spectrin; alpha-spectrin; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097205.1 → NP_001090674.1 spectrin alpha chain, non-erythrocytic 1

See identical proteins and their annotated locations for NP_001090674.1

Status: PROVISIONAL

Source sequence(s)

BC127322

UniProtKB/TrEMBL

A0A6I8QQI3, A0JPA2

Related

ENSXETP00000075428.2, ENSXETT00000082315.2

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2326 → 2394

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:2401 → 2469

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam00435
Location:1657 → 1759

Spectrin; Spectrin repeat

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

22655947..22694414 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031906808.1 → XP_031762668.1 spectrin alpha chain, non-erythrocytic 1 isoform X7

UniProtKB/TrEMBL

A0A6I8QQI3, A0A8J1JXP9

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2306 → 2374

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1637 → 1741

Spectrin; Spectrin repeat

pfam08726
Location:2381 → 2449

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_031906807.1 → XP_031762667.1 spectrin alpha chain, non-erythrocytic 1 isoform X6

UniProtKB/TrEMBL

A0A6I8R173, A0A8J1JXP0

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2311 → 2379

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1642 → 1746

Spectrin; Spectrin repeat

pfam08726
Location:2386 → 2454

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_031906804.1 → XP_031762664.1 spectrin alpha chain, non-erythrocytic 1 isoform X3

UniProtKB/TrEMBL

A0A8J1JXN7, F7CA69

Related

ENSXETP00000085482.2, ENSXETT00000090400.2

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2332 → 2400

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1642 → 1746

Spectrin; Spectrin repeat

pfam08726
Location:2407 → 2475

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_031906803.1 → XP_031762663.1 spectrin alpha chain, non-erythrocytic 1 isoform X2

UniProtKB/TrEMBL

A0A6I8QBU0, F7CA69

Related

ENSXETP00000066883.2, ENSXETT00000081411.2

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2347 → 2415

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1657 → 1761

Spectrin; Spectrin repeat

pfam08726
Location:2422 → 2490

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_031906806.1 → XP_031762666.1 spectrin alpha chain, non-erythrocytic 1 isoform X5

UniProtKB/TrEMBL

A0A6I8QQI3, A0A8J1K1V2

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2325 → 2393

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1662 → 1766

Spectrin; Spectrin repeat

pfam08726
Location:2400 → 2468

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_031906805.1 → XP_031762665.1 spectrin alpha chain, non-erythrocytic 1 isoform X4

UniProtKB/TrEMBL

A0A6I8R173, A0A8J1K0B6

Related

ENSXETP00000078248.2, ENSXETT00000073786.2

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2331 → 2399

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1662 → 1766

Spectrin; Spectrin repeat

pfam08726
Location:2406 → 2474

EFhand_Ca_insen; Ca2+ insensitive EF hand
XM_031906802.1 → XP_031762662.1 spectrin alpha chain, non-erythrocytic 1 isoform X1

UniProtKB/TrEMBL

A0A6I8SVI1, F7CA69

Related

ENSXETP00000097221.2, ENSXETT00000086364.2

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2352 → 2420

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1662 → 1766

Spectrin; Spectrin repeat

pfam08726
Location:2427 → 2495

EFhand_Ca_insen; Ca2+ insensitive EF hand