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    mfsd6a major facilitator superfamily domain containing 6a [ Danio rerio (zebrafish) ]

    Gene ID: 100034426, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mfsd6aprovided by ZNC
    Official Full Name
    major facilitator superfamily domain containing 6aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-335
    See related
    Ensembl:ENSDARG00000032318 AllianceGenome:ZFIN:ZDB-GENE-050208-335
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mfsd6; si:dkey-188p4.2
    Summary
    Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human MFSD6 (major facilitator superfamily domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mfsd6a in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (12911222..12930488, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (12886445..12905700, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene glutaminase a Neighboring gene NGFI-A binding protein 1a (EGR1 binding protein 1) Neighboring gene leucine-rich repeat-containing protein 15 Neighboring gene aryl hydrocarbon receptor 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Perland E, et al. Open Biol, 2017 Sep. PMID 28878041, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 6-A
    Names
    macrophage MHC class I receptor 2 homolog A
    major facilitator superfamily domain containing 6
    major facilitator superfamily domain-containing protein 6
    mfds6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083056.1 → NP_001076525.1  major facilitator superfamily domain-containing protein 6-A

      See identical proteins and their annotated locations for NP_001076525.1

      Status: PROVISIONAL

      Source sequence(s)
      BX927260
      UniProtKB/Swiss-Prot
      Q1LUQ4
      Related
      ENSDARP00000063028.5, ENSDART00000063029.7
      Conserved Domains (3) summary
      cd06174
      Location:461 → 632
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:461 → 659
      MFS_1; Major Facilitator Superfamily
      pfam12832
      Location:69 → 144
      MFS_1_like; MFS_1 like family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      12911222..12930488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161679.5 → XP_005161736.1  major facilitator superfamily domain-containing protein 6-A isoform X1

      See identical proteins and their annotated locations for XP_005161736.1

      UniProtKB/Swiss-Prot
      Q1LUQ4
      Conserved Domains (3) summary
      cd06174
      Location:461 → 632
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:461 → 659
      MFS_1; Major Facilitator Superfamily
      pfam12832
      Location:69 → 144
      MFS_1_like; MFS_1 like family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1LUQ4.1 GenPept UniProtKB/Swiss-Prot:Q1LUQ4

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