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    ZNF182 zinc finger protein 182 [ Homo sapiens (human) ]

    Gene ID: 7569, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF182provided by HGNC
    Official Full Name
    zinc finger protein 182provided by HGNC
    Primary source
    HGNC:HGNC:13001
    See related
    Ensembl:ENSG00000147118 MIM:314993; AllianceGenome:HGNC:13001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX14; ZNF21; HHZ150; Zfp182
    Summary
    Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.7), lymph node (RPKM 3.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF182 in Genome Data Viewer
    Location:
    Xp11.23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (47974851..48003989, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (47385028..47414166, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47834250..47863388, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:47665811-47666441 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:47675037-47676236 Neighboring gene WASP family member 4, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29598 Neighboring gene ribosomal protein L7 pseudogene 57 Neighboring gene zinc finger protein 81 Neighboring gene CRISPRi-FlowFISH-validated HDAC6 regulatory element 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20813 Neighboring gene sperm acrosome associated 5 Neighboring gene ZNF630 antisense RNA 1 Neighboring gene zinc finger protein 630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescence in situ hybridization. Wang R, et al. Somat Cell Mol Genet, 1996 May. PMID 8914609
    2. Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1. Knight JC, et al. Genomics, 1994 May 1. PMID 8088786
    3. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article
    4. Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation. Okada M, et al. Mol Endocrinol, 2015 Nov. PMID 26389696, Free PMC Article
    5. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 182 (ZNF182) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ98691, MGC125383, MGC131713

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 182
    Names
    zinc finger protein 21 (KOX 14)
    zinc finger protein KOX14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021254.2 RefSeqGene

      Range
      5000..34138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007088.2 → NP_001007089.1  zinc finger protein 182 isoform 2

      See identical proteins and their annotated locations for NP_001007089.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, resulting in an upstream AUG start codon, as compared to variant 1. The encoded isoform 2 is shorter and has an alternate N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC244636, AK122874, AW291763, BX648401, CN311292
      Consensus CDS
      CCDS35235.1
      UniProtKB/Swiss-Prot
      P17025
      Related
      ENSP00000366142.4, ENST00000376943.8
      Conserved Domains (3) summary
      smart00349
      Location:8 → 66
      KRAB; krueppel associated box
      COG5048
      Location:213 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:525 → 545
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001178099.2 → NP_001171570.1  zinc finger protein 182 isoform 1

      See identical proteins and their annotated locations for NP_001171570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional segment in the 5' UTR, as compared to variant 1. This variant and variant 1 encode the same isoform (1).
      Source sequence(s)
      AK122874, BC114216, DC377274
      Consensus CDS
      CCDS35236.1
      UniProtKB/Swiss-Prot
      A2IDD7, P17025, Q3KP67, Q96QH7
      Related
      ENSP00000380165.1, ENST00000396965.5
      Conserved Domains (6) summary
      smart00349
      Location:27 → 85
      KRAB; krueppel associated box
      COG5048
      Location:147 → 553
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:544 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:374 → 396
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:587 → 609
      zf-H2C2_2; Zinc-finger double domain

    3. NM_006962.2 → NP_008893.1  zinc finger protein 182 isoform 1

      See identical proteins and their annotated locations for NP_008893.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC244636, AK122874, AW291763, BX648401, CD642892
      Consensus CDS
      CCDS35236.1
      UniProtKB/Swiss-Prot
      A2IDD7, P17025, Q3KP67, Q96QH7
      Conserved Domains (6) summary
      smart00349
      Location:27 → 85
      KRAB; krueppel associated box
      COG5048
      Location:147 → 553
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:544 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:374 → 396
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:587 → 609
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      47974851..48003989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      47385028..47414166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17025.2 GenPept UniProtKB/Swiss-Prot:P17025

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