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    Rabl3 RAB, member RAS oncogene family-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 67657, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rabl3provided by MGI
    Official Full Name
    RAB, member RAS oncogene family-like 3provided by MGI
    Primary source
    MGI:MGI:1914907
    See related
    Ensembl:ENSMUSG00000022827 AllianceGenome:MGI:1914907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930553C05Rik
    Summary
    Enables GTP binding activity and protein homodimerization activity. Involved in lymphocyte differentiation and protein stabilization. Predicted to be active in endomembrane system. Is expressed in acoustic ganglion; otocyst; and urinary system. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RABL3 (RAB, member of RAS oncogene family like 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.5), CNS E11.5 (RPKM 5.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rabl3 in Genome Data Viewer
    Location:
    16 B3; 16 26.39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (37360220..37392747)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (37539858..37572385)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 5-like Neighboring gene predicted gene, 57640 Neighboring gene STARR-seq mESC enhancer starr_40783 Neighboring gene STARR-positive B cell enhancer ABC_E2461 Neighboring gene general transcription factor II E, polypeptide 1 (alpha subunit) Neighboring gene predicted gene, 46559 Neighboring gene STARR-positive B cell enhancer ABC_E7447 Neighboring gene homogentisate 1, 2-dioxygenase Neighboring gene NADH:ubiquinone oxidoreductase subunit B4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function. Zhong X, et al. Proc Natl Acad Sci U S A, 2020 Apr 14. PMID 32220963, Free PMC Article
    2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein lipidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein lipidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rab-like protein 3
    Names
    RAB, member of RAS oncogene family-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042499.1 → NP_001035964.1  rab-like protein 3

      See identical proteins and their annotated locations for NP_001035964.1

      Status: VALIDATED

      Source sequence(s)
      AC154762, AK016099
      Consensus CDS
      CCDS37338.1
      UniProtKB/Swiss-Prot
      Q8BMU2, Q9D0M6, Q9D4V7
      Related
      ENSMUSP00000023524.7, ENSMUST00000023524.13
      Conserved Domains (1) summary
      cd04102
      Location:7 → 210
      RabL3; Rab GTPase-like family 3 (Rab-like3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      37360220..37392747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160101.1 → XP_036015994.1  rab-like protein 3 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:7 → 154
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_384595.1 RNA Sequence

      Related
      ENSMUST00000130028.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026297.1: Suppressed sequence

      Description
      NM_026297.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4V7.1 GenPept UniProtKB/Swiss-Prot:Q9D4V7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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