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    APOA4 apolipoprotein A4 [ Bos taurus (domestic cattle) ]

    Gene ID: 537301, updated on 10-Oct-2024

    Summary

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    Official Symbol
    APOA4provided by VGNC
    Official Full Name
    apolipoprotein A4provided by VGNC
    Primary source
    VGNC:VGNC:26024
    See related
    BGD:BT16567; Ensembl:ENSBTAG00000019770
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See APOA4 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (27477953..27490905, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene splicing factor 3B subunit 4-like Neighboring gene apolipoprotein A5 Neighboring gene apolipoprotein C-III Neighboring gene uncharacterized LOC104974207 Neighboring gene apolipoprotein C3 Neighboring gene apolipoprotein A1 Neighboring gene SIK family kinase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127813

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylcholine-sterol O-acyltransferase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cholesterol efflux IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in high-density lipoprotein particle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phospholipid efflux IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in reverse cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in very-low-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in blood microparticle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of chylomicron IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apolipoprotein A-IV
    Names
    apo-AIV
    apoA-IV

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037480.1 → NP_001032557.1  apolipoprotein A-IV precursor

      See identical proteins and their annotated locations for NP_001032557.1

      Status: PROVISIONAL

      Source sequence(s)
      BC108096
      UniProtKB/Swiss-Prot
      Q32PJ2
      UniProtKB/TrEMBL
      A0A3Q1M3N0
      Conserved Domains (3) summary
      pfam01442
      Location:66 → 235
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam02601
      Location:137 → 201
      Exonuc_VII_L; Exonuclease VII, large subunit
      cl19726
      Location:66 → 182
      DUF2884; Protein of unknown function (DUF2884)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27477953..27490905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005215852.5 → XP_005215909.1  apolipoprotein A-IV isoform X1

      See identical proteins and their annotated locations for XP_005215909.1

      UniProtKB/TrEMBL
      A0A3Q1M3N0
      Related
      ENSBTAP00000068128.1, ENSBTAT00000086907.2
      Conserved Domains (3) summary
      pfam01442
      Location:91 → 260
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl19726
      Location:91 → 207
      DUF2884; Protein of unknown function (DUF2884)
      cl21509
      Location:207 → 314
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    2. XM_010812370.4 → XP_010810672.1  apolipoprotein A-IV isoform X1

      See identical proteins and their annotated locations for XP_010810672.1

      UniProtKB/TrEMBL
      A0A3Q1M3N0
      Related
      ENSBTAP00000026345.5, ENSBTAT00000026345.5
      Conserved Domains (3) summary
      pfam01442
      Location:91 → 260
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl19726
      Location:91 → 207
      DUF2884; Protein of unknown function (DUF2884)
      cl21509
      Location:207 → 314
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    3. XM_015474619.3 → XP_015330105.1  apolipoprotein A-IV isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M3N0
      Conserved Domains (1) summary
      pfam01442
      Location:66 → 235
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    4. XM_059874884.1 → XP_059730867.1  apolipoprotein A-IV isoform X2

    5. XM_059874885.1 → XP_059730868.1  apolipoprotein A-IV isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32PJ2.1 GenPept UniProtKB/Swiss-Prot:Q32PJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials