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    ACTA2 actin, alpha 2, smooth muscle, aorta [ Gallus gallus (chicken) ]

    Gene ID: 423787, updated on 10-Oct-2024

    Summary

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    Symbol
    ACTA2provided by CGNC
    Full Name
    actin, alpha 2, smooth muscle, aortaprovided by CGNC
    Primary source
    CGNC:52051
    See related
    Ensembl:ENSGALG00010022071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    asma
    Orthologs
    human mouse all
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    Genomic context

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    See ACTA2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (19993995..20050197, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (19980916..20037141, complement)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene lipase member M-like 4 Neighboring gene STAM binding protein like 1 Neighboring gene Fas cell surface death receptor Neighboring gene cholesterol 25-hydroxylase Neighboring gene lipase A, lysosomal acid type

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased arterial load alters aortic structural and functional properties during embryogenesis. Lucitti JL, et al. Am J Physiol Heart Circ Physiol, 2006 Oct. PMID 16648183
    2. Structure and complete nucleotide sequence of the chicken alpha-smooth muscle (aortic) actin gene. An actin gene which produces multiple messenger RNAs. Carroll SL, et al. J Biol Chem, 1986 Jul 5. PMID 3013870
    3. Pericytes in the mature chorioallantoic membrane capillary plexus contain desmin and alpha-smooth muscle actin: relevance for non-sprouting angiogenesis. Kurz H, et al. Histochem Cell Biol, 2008 Nov. PMID 18688635
    4. Antisense oligodeoxynucleotide complementary to smooth muscle alpha-actin inhibits endothelial-mesenchymal transformation during chick cardiogenesis. Nakajima Y, et al. Dev Dyn, 1999 Dec. PMID 10633868
    5. Isolation and characterization of six different chicken actin genes. Chang KS, et al. Mol Cell Biol, 1984 Nov. PMID 6513927, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction.
      Title: Comparative expression of laminin and smooth muscle actin in the testis and epididymis of poultry and rabbit.
    2. Pericytes in the mature chorioallantoic membrane capillary plexus contain desmin and alpha-smooth muscle actin: relevance for non-sprouting angiogenesis.
      Title: Pericytes in the mature chorioallantoic membrane capillary plexus contain desmin and alpha-smooth muscle actin: relevance for non-sprouting angiogenesis.
    3. Thus the embryonic dorsal aorta is sensitive to increased arterial load and adapts by altering its material properties via changes in collagen and alpha-actin content.
      Title: Increased arterial load alters aortic structural and functional properties during embryogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    actin, aortic smooth muscle
    Names
    alpha-actin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031229.2 → NP_001026400.2  actin, aortic smooth muscle

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000231
      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476
      Related
      ENSGALP00010032334.1, ENSGALT00010053682.1
      Conserved Domains (1) summary
      PTZ00281
      Location:3 → 377
      PTZ00281; actin; Provisional

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      19993995..20050197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015288392.4 → XP_015143878.1  actin, aortic smooth muscle isoform X1

      UniProtKB/Swiss-Prot
      P08023
      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476
      Conserved Domains (1) summary
      PTZ00281
      Location:3 → 377
      PTZ00281; actin; Provisional

    2. XM_046942894.1 → XP_046798850.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    3. XM_046942896.1 → XP_046798852.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    4. XM_046942898.1 → XP_046798854.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    5. XM_046942897.1 → XP_046798853.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    6. XM_046942902.1 → XP_046798858.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    7. XM_046942901.1 → XP_046798857.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    8. XM_046942899.1 → XP_046798855.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    9. XM_046942900.1 → XP_046798856.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    10. XM_046942895.1 → XP_046798851.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      19980916..20037141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046920238.1 → XP_046776194.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    2. XM_046920234.1 → XP_046776190.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    3. XM_046920237.1 → XP_046776193.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    4. XM_046920240.1 → XP_046776196.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    5. XM_046920239.1 → XP_046776195.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    6. XM_046920244.1 → XP_046776200.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    7. XM_046920243.1 → XP_046776199.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    8. XM_046920242.1 → XP_046776198.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    9. XM_046920233.1 → XP_046776189.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    10. XM_046920241.1 → XP_046776197.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476

    11. XM_046920236.1 → XP_046776192.1  actin, aortic smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A1I7Q414, A0A1L1RXB8, F1P476
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08023.2 GenPept UniProtKB/Swiss-Prot:P08023

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