fgfr3.S fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: fgfr3.S
Official Full Name: fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog
Primary source: Xenbase:XB-GENE-17330101
Locus tag: XELAEV_18008865mg
See related: EnsemblRapid:ENSXLAG00005025068 AllianceGenome:Xenbase:XB-GENE-17330101
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ach; cek2; jtk4; cd333; fgfr3; hsfgfr3ex
Summary: Predicted to enable ATP binding activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor activity. Predicted to act upstream of or within several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of kinase activity. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 1S

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (12167504..12243488)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (12021994..12097941)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor receptor 3

Names: FGF receptor 3; FGFR-3

NP_001084170.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090701.1 → NP_001084170.1 fibroblast growth factor receptor 3

See identical proteins and their annotated locations for NP_001084170.1

Status: PROVISIONAL

Source sequence(s)

AB007035

UniProtKB/Swiss-Prot

O42127

UniProtKB/TrEMBL

A0A974DT03

Related

ENSXLAP00005074357.1, ENSXLAT00005075937.1

Conserved Domains (7) summary

cd04974
Location:257 → 344

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:150 → 234

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05100
Location:449 → 782

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:44 → 99

IGc2; Immunoglobulin C-2 Type

smart00409
Location:45 → 115

IG; Immunoglobulin

smart00410
Location:249 → 343

IG_like; Immunoglobulin like

pfam07714
Location:462 → 738

Pkinase_Tyr; Protein tyrosine kinase