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    HP haptoglobin [ Sus scrofa (pig) ]

    Gene ID: 397061, updated on 5-Mar-2024

    Summary

    Gene symbol
    HP
    Gene description
    haptoglobin
    See related
    Ensembl:ENSSSCG00000002749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in liver (RPKM 10246.7) and mixtures (RPKM 3844.5) See more
    Orthologs
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    Genomic context

    Location:
    chromosome: 6
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (14980382..14985245)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (14643378..14648241)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102158108 Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene dihydroorotate dehydrogenase (quinone) Neighboring gene thioredoxin like 4B Neighboring gene DEAH-box helicase 38 Neighboring gene polyamine modulated factor 1 binding protein 1 Neighboring gene uncharacterized LOC110260920

    Genomic regions, transcripts, and products

    Expression

    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hemoglobin binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    haptoglobin
    Names
    haptoglobin alpha 1S
    zonulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214000.2NP_999165.1  haptoglobin precursor

      See identical proteins and their annotated locations for NP_999165.1

      Status: VALIDATED

      Source sequence(s)
      AK232478, CJ004687
      UniProtKB/Swiss-Prot
      Q8SPS7
      UniProtKB/TrEMBL
      B3GQZ2
      Related
      ENSSSCP00000002967.3, ENSSSCT00000003046.4
      Conserved Domains (2) summary
      cd00033
      Location:3387
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00190
      Location:103343
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      14980382..14985245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005664359.2XP_005664416.1  haptoglobin isoform X1

      UniProtKB/TrEMBL
      A0A8D0LMR0
      Conserved Domains (2) summary
      smart00020
      Location:56294
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:57297
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...