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    Rap2l Ras-associated protein 2-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37850, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rap2lprovided by FlyBase
    Official Full Name
    Ras-associated protein 2-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283666
    Locus tag
    Dmel_CG3204
    See related
    AllianceGenome:FB:FBgn0283666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3204; Dm Rap21; Dmel\CG3204; l(2)SH0581; l(2)SH2 0581; O96692; Rap2; Rap21; Rap2L
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in germ-line stem cell population maintenance. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and adult heart. Orthologous to several human genes including RAP2C (RAP2C, member of RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Rap2l in Genome Data Viewer
    Location:
    60B7-60B7; 2-106 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24063051..24065405)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19950574..19952928)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44814 Neighboring gene eukaryotic translation elongation factor 5 Neighboring gene Ribosomal protein L12 Neighboring gene Ribosomal protein L39 Neighboring gene yorkie Neighboring gene Glycerol-3-phosphate acyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rap-GEF/Rap signaling restricts the formation of supernumerary spermathecae in Drosophila melanogaster. Singh SR, et al. Dev Growth Differ, 2006 Apr. PMID 16573734
    2. The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster. Shirinian M, et al. PLoS One, 2010 Mar 3. PMID 20209136, Free PMC Article
    3. A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Aging Drosophila Neurons. Vagnoni A, et al. Curr Biol, 2018 Apr 23. PMID 29606421, Free PMC Article
    4. Differences in temperature-sensitive expression of PcG-regulated genes among natural populations of Drosophila melanogaster. Voigt S, et al. G3 (Bethesda), 2021 Sep 6. PMID 34544136, Free PMC Article
    5. Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Wang H, et al. Dev Cell, 2006 Jan. PMID 16399083

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Rap protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Rap protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in germ-line stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ras-associated protein 2-like
    Names
    CG3204-PA
    CG3204-PC
    CG3204-PD
    Rap2l-PA
    Rap2l-PC
    Rap2l-PD
    lethal (2) SH0581

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24063051..24065405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058054.4 → NP_477402.1  Ras-associated protein 2-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477402.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96692
      Related
      FBpp0072086
      Conserved Domains (1) summary
      cd04176
      Location:16 → 165
      Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

    2. NM_001299887.1 → NP_001286816.1  Ras-associated protein 2-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286816.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGJ4
      Conserved Domains (1) summary
      cl21455
      Location:1 → 99
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001299888.1 → NP_001286817.1  Ras-associated protein 2-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286817.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGJ4
      Conserved Domains (1) summary
      cl21455
      Location:1 → 99
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGJ4 A0A0B4LGJ4
    O96692 O96692
    Q95SU2 Q95SU2

    Gene LinkOut

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