Ska3 spindle and kinetochore associated complex subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ska3provided by RGD
Official Full Name: spindle and kinetochore associated complex subunit 3provided by RGD
Primary source: RGD:1307201
See related: EnsemblRapid:ENSRNOG00000021847 AllianceGenome:RGD:1307201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307201
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in establishment of meiotic spindle orientation; nuclear chromosome segregation; and regulation of organelle organization. Predicted to be located in centrosome; cytosol; and mitotic spindle. Predicted to be part of SKA complex. Predicted to be active in kinetochore and spindle microtubule. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 79.2), Spleen (RPKM 55.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (36067372..36086563, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (31951812..31971010, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (38077903..38097100, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH140692 (e-PCR)
- UniSTS:222760

RH143635 (e-PCR)
- UniSTS:232881

AV005697 (e-PCR)
- UniSTS:164553

BF386294 (e-PCR)
- UniSTS:243658

RH140624 (e-PCR)
- UniSTS:222693

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in attachment of mitotic spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in establishment of meiotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule polymerization or depolymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization or depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle assembly involved in female meiosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SKA complex	IEA Inferred from Electronic Annotation more info
part_of SKA complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
part_of outer kinetochore	IBA Inferred from Biological aspect of Ancestor more info
part_of outer kinetochore	IEA Inferred from Electronic Annotation more info
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info
part_of outer kinetochore	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SKA complex subunit 3; spindle and kinetochore-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108379.3 → NP_001101849.1 SKA complex subunit 3 isoform 2

See identical proteins and their annotated locations for NP_001101849.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

A6KHD2, B2GUZ2

UniProtKB/TrEMBL

A0A8I5Y7E4, A0A8L2QHE9

Related

ENSRNOP00000077309.1, ENSRNOT00000117004.2

Conserved Domains (1) summary

cd12957
Location:3 → 101

SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain
NM_001431685.1 → NP_001418614.1 SKA complex subunit 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015
NM_001431688.1 → NP_001418617.1 SKA complex subunit 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015
NM_001431690.1 → NP_001418619.1 SKA complex subunit 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

A6KHD2, B2GUZ2

UniProtKB/TrEMBL

A0A8L2QHE9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

36067372..36086563 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252074.3 → XP_006252136.1 spindle and kinetochore-associated protein 3 isoform X1

Related

ENSRNOP00000033626.6, ENSRNOT00000032723.6

Conserved Domains (1) summary

cd12957
Location:3 → 102

SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain
XM_006252075.3 → XP_006252137.1 spindle and kinetochore-associated protein 3 isoform X1

Conserved Domains (1) summary

cd12957
Location:3 → 102

SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain
XM_063274410.1 → XP_063130480.1 spindle and kinetochore-associated protein 3 isoform X2
XM_063274411.1 → XP_063130481.1 spindle and kinetochore-associated protein 3 isoform X3