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    Su(var)2-10 Suppressor of variegation 2-10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35927, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Su(var)2-10provided by FlyBase
    Official Full Name
    Suppressor of variegation 2-10provided by FlyBase
    Primary source
    FLYBASE:FBgn0003612
    Locus tag
    Dmel_CG8068
    See related
    AllianceGenome:FB:FBgn0003612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8068; CLOT2057; Dmel\CG8068; DmPias; dpias; dPIAS; Dpias; DPIAS; i184; l(2)03697; pias; PIAS; Su(var)-10; Su(Var)2-10; SU(VAR)2-10; Su-var(2)10; Suvar(2)10; Sv210; zimp; ZIMP; ZimpA; ZimpB
    Summary
    Enables STAT family protein binding activity and SUMO ligase activity. Involved in several processes, including piRNA-mediated retrotransposon silencing by heterochromatin formation; positive regulation of somatic stem cell division; and regulation of signal transduction. Located in chromosome, telomeric region; cytoplasm; and nuclear lumen. Is expressed in egg chamber; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord. Used to study hematologic cancer. Orthologous to several human genes including PIAS2 (protein inhibitor of activated STAT 2) and PIAS3 (protein inhibitor of activated STAT 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Su(var)2-10 in Genome Data Viewer
    Location:
    45A8-45A9; 2-60 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9116122..9122000)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5003627..5009505)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Mystery 45A Neighboring gene tsunagi Neighboring gene Phosphorylated adaptor for RNA export Neighboring gene Glutathione S transferase E13 Neighboring gene uncharacterized protein Neighboring gene alpha/beta hydrolase 1 Neighboring gene alicorn

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation. O'Rourke JG, et al. Cell Rep, 2013 Jul 25. PMID 23871671, Free PMC Article
    2. Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation. Skora AD, et al. Proc Natl Acad Sci U S A, 2010 Apr 20. PMID 20368445, Free PMC Article
    3. A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases. Jackson PK. Genes Dev, 2001 Dec 1. PMID 11731472
    4. Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene in Drosophila melanogaster. Mohr SE, et al. Gene, 1999 Mar 18. PMID 10095110
    5. Direct interaction of Su(var)2-10 via the SIM-binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster. Bence M, et al. FEBS J, 2024 Apr. PMID 38308815

    See all (153) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Direct interaction of Su(var)2-10 via the SIM-binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster.
      Title: Direct interaction of Su(var)2-10 via the SIM-binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables STAT family protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables SUMO ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc growth TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in piRNA-mediated retrotransposon silencing by heterochromatin formation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of innate immune response HMP PubMed 
    involved_in positive regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of somatic stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppressor of variegation 2-10
    Names
    CG8068-PA
    CG8068-PB
    CG8068-PC
    CG8068-PD
    CG8068-PE
    CG8068-PF
    CG8068-PG
    CG8068-PH
    CG8068-PI
    CG8068-PJ
    CG8068-PK
    CG8068-PL
    CG8068-PM
    CG8068-PN
    Su(var)2-10-PA
    Su(var)2-10-PB
    Su(var)2-10-PC
    Su(var)2-10-PD
    Su(var)2-10-PE
    Su(var)2-10-PF
    Su(var)2-10-PG
    Su(var)2-10-PH
    Su(var)2-10-PI
    Su(var)2-10-PJ
    Su(var)2-10-PK
    Su(var)2-10-PL
    Su(var)2-10-PM
    Su(var)2-10-PN
    protein inhibitor of activated STAT
    zinc finger-containing Miz1 PIAS3-like
    NP_001286228.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9116122..9122000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201959.2 → NP_001188888.1  suppressor of variegation 2-10, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD33, C1C3E9
      Conserved Domains (3) summary
      smart00513
      Location:49 → 83
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:368 → 417
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:171 → 307
      PINIT; PINIT domain

    2. NM_001299299.1 → NP_001286228.1  suppressor of variegation 2-10, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEH9, C1C3E9
      Conserved Domains (3) summary
      smart00513
      Location:49 → 83
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:368 → 417
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:171 → 307
      PINIT; PINIT domain

    3. NM_001259286.2 → NP_001246215.1  suppressor of variegation 2-10, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246215.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6T9, C1C3E9
      Conserved Domains (3) summary
      smart00513
      Location:49 → 83
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:368 → 417
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:171 → 307
      PINIT; PINIT domain

    4. NM_165645.2 → NP_724749.1  suppressor of variegation 2-10, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7P5, C1C3E9
      Related
      FBpp0087651
      Conserved Domains (3) summary
      smart00513
      Location:49 → 83
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:368 → 417
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:171 → 307
      PINIT; PINIT domain

    5. NM_165647.3 → NP_724751.1  suppressor of variegation 2-10, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724751.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7P7, C1C3E9
      Related
      FBpp0087652
      Conserved Domains (3) summary
      smart00513
      Location:49 → 83
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:368 → 417
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:171 → 307
      PINIT; PINIT domain

    6. NM_165646.2 → NP_724750.1  suppressor of variegation 2-10, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3E9, Q8IGK3
      Related
      FBpp0087653
      Conserved Domains (3) summary
      smart00513
      Location:49 → 83
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:368 → 417
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:171 → 307
      PINIT; PINIT domain

    7. NM_001201957.2 → NP_001188886.1  suppressor of variegation 2-10, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD03, C1C3E9
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:321 → 370
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:124 → 260
      PINIT; PINIT domain

    8. NM_001201958.2 → NP_001188887.1  suppressor of variegation 2-10, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCQ7, C1C3E9
      Conserved Domains (3) summary
      smart00513
      Location:13 → 47
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:332 → 381
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:135 → 271
      PINIT; PINIT domain

    9. NM_165648.3 → NP_724752.1  suppressor of variegation 2-10, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7P8, C1C3E9
      Related
      FBpp0087656
      Conserved Domains (3) summary
      smart00513
      Location:13 → 47
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:332 → 381
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:135 → 271
      PINIT; PINIT domain

    10. NM_165651.2 → NP_724755.1  suppressor of variegation 2-10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Q1, C1C3E9
      Related
      FBpp0087658
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:321 → 370
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:124 → 260
      PINIT; PINIT domain

    11. NM_165649.2 → NP_724753.1  suppressor of variegation 2-10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7P9, C1C3E9
      Related
      FBpp0087654
      Conserved Domains (3) summary
      smart00513
      Location:13 → 47
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:332 → 381
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:135 → 271
      PINIT; PINIT domain

    12. NM_165652.3 → NP_724756.1  suppressor of variegation 2-10, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3E9, Q9XYM5
      Related
      FBpp0087657
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:321 → 370
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:124 → 260
      PINIT; PINIT domain

    13. NM_078940.3 → NP_523664.1  suppressor of variegation 2-10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3E9, Q7KNF5
      Related
      FBpp0087659
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:321 → 370
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:124 → 260
      PINIT; PINIT domain

    14. NM_165650.3 → NP_724754.1  suppressor of variegation 2-10, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3E9, Q5BIG7
      Related
      FBpp0087655
      Conserved Domains (3) summary
      smart00513
      Location:13 → 47
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:332 → 381
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:135 → 271
      PINIT; PINIT domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCQ7 A0A0B4JCQ7
    A0A0B4JD03 A0A0B4JD03
    A0A0B4JD33 A0A0B4JD33
    A0A0B4K6T9 A0A0B4K6T9
    A0A0B4LEH9 A0A0B4LEH9
    A1Z7P5 A1Z7P5
    A1Z7P7 A1Z7P7
    A1Z7P8 A1Z7P8
    A1Z7P9 A1Z7P9
    A1Z7Q1 A1Z7Q1
    Q5BIG7 Q5BIG7
    Q7KNF5 Q7KNF5
    Q8IGK3 Q8IGK3
    Q9XYM5 Q9XYM5

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