FES FES proto-oncogene, tyrosine kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: FESprovided by HGNC
Official Full Name: FES proto-oncogene, tyrosine kinaseprovided by HGNC
Primary source: HGNC:HGNC:3657
See related: Ensembl:ENSG00000182511 MIM:190030; AllianceGenome:HGNC:3657
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FPS
Summary: This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
Expression: Broad expression in spleen (RPKM 39.1), bone marrow (RPKM 25.6) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q26.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (90884504..90895776)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (88643915..88655365)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (91427734..91439006)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.
Title: The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.
Identification of FES as a Novel Radiosensitizing Target in Human Cancers.
Title: Identification of FES as a Novel Radiosensitizing Target in Human Cancers.
This study supports the critical role of FER and FES tyrosine kinase fusions in the pathogenesis of follicular T-cell lymphoma and provides additional evidence that these can drive follicular T-cell lymphoma in the absence of RHOA mutations.
Title: FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.
analysis of the JAK-Fes-phospholipase D signaling pathway that is enhanced in highly proliferative breast cancer cells
Title: A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells.
c-fes gene expression was found in myeloid leukemias, whereas low or no expression in lymphocytic leukemias.
Title: [Expression of c-fes gene in leukemia cells and its clinical significance].
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
FES kinase is a mediator of wild-type KIT signalling implicated in cell migration.
Title: FES kinase participates in KIT-ligand induced chemotaxis.
FGF-2 activates Fes via the second coiled-coil domain, leading to lamellipodium formation and chemotaxis by endothelial cells
Title: Inhibition of endothelial cell chemotaxis toward FGF-2 by gefitinib associates with downregulation of Fes activity.
c-Fes oligomerization is independent of activation; data suggest that conformational changes, rather than oligomerization, govern c-Fes kinase activation and downstream signaling in vivo.
Title: Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93529 (e-PCR)
- UniSTS:85008

RH1636 (e-PCR)
- UniSTS:24856

G54068 (e-PCR)
- UniSTS:109450

STS-X52192 (e-PCR)
- UniSTS:64172

GDB:180414 (e-PCR)
- UniSTS:155100

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables immunoglobulin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to vitamin D	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule bundle formation	IEA Inferred from Electronic Annotation more info
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase Fes/Fps

Names: Oncogene FES, feline sarcoma virus; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog; feline sarcoma oncogene; feline sarcoma/Fujinami avian sarcoma oncogene homolog; p93c-fes; proto-oncogene c-Fes; proto-oncogene c-Fps; proto-oncogene tyrosine-protein kinase Fes/Fps

NP_001137255.1

EC 2.7.10.2

NP_001137256.1

EC 2.7.10.2

NP_001137257.1

EC 2.7.10.2

NP_001996.1

EC 2.7.10.2

XP_005254937.1

EC 2.7.10.2

XP_005254939.1

EC 2.7.10.2

XP_016877494.1

EC 2.7.10.2

XP_016877495.1

EC 2.7.10.2

XP_016877496.1

EC 2.7.10.2

XP_016877497.1

EC 2.7.10.2

XP_016877498.1

EC 2.7.10.2

XP_016877499.1

EC 2.7.10.2

XP_047288189.1

EC 2.7.10.2

XP_047288190.1

EC 2.7.10.2

XP_047288191.1

EC 2.7.10.2

XP_047288192.1

EC 2.7.10.2

XP_047288193.1

EC 2.7.10.2

XP_047288194.1

EC 2.7.10.2

XP_047288195.1

EC 2.7.10.2

XP_054233470.1

EC 2.7.10.2

XP_054233471.1

EC 2.7.10.2

XP_054233472.1

EC 2.7.10.2

XP_054233473.1

EC 2.7.10.2

XP_054233474.1

EC 2.7.10.2

XP_054233475.1

EC 2.7.10.2

XP_054233476.1

EC 2.7.10.2

XP_054233477.1

EC 2.7.10.2

XP_054233478.1

EC 2.7.10.2

XP_054233479.1

EC 2.7.10.2

XP_054233480.1

EC 2.7.10.2

XP_054233481.1

EC 2.7.10.2

XP_054233482.1

EC 2.7.10.2

XP_054233483.1

EC 2.7.10.2

XP_054233484.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029671.1 RefSeqGene

Range

5047..16319

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001143783.1 → NP_001137255.1 tyrosine-protein kinase Fes/Fps isoform 2

See identical proteins and their annotated locations for NP_001137255.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC124248, AY513656

Consensus CDS

CCDS45350.1

UniProtKB/TrEMBL

B4DUD9

Related

ENSP00000377837.3, ENST00000394300.7

Conserved Domains (4) summary

cd10361
Location:395 → 479

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cd05084
Location:506 → 757

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:503 → 756

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:7 → 181

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001143784.1 → NP_001137256.1 tyrosine-protein kinase Fes/Fps isoform 3

See identical proteins and their annotated locations for NP_001137256.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a protein (isoform 3) with a shorter C-terminus and an incomplete SH2 domain, compared to isoform 1.

Source sequence(s)

AC124248, AY513657

Consensus CDS

CCDS45349.1

UniProtKB/TrEMBL

B4DUD9

Related

ENSP00000400868.2, ENST00000444422.2

Conserved Domains (3) summary

cd05084
Location:494 → 745

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:491 → 744

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:7 → 239

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001143785.2 → NP_001137257.1 tyrosine-protein kinase Fes/Fps isoform 4

See identical proteins and their annotated locations for NP_001137257.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks multiple in-frame exons in the coding region, compared to variant 1, and encodes a shorter protein (isoform 4) with an incomplete SH2 domain, compared to isoform 1.

Source sequence(s)

AC124248, AY513654, DB264752

Consensus CDS

CCDS45351.1

UniProtKB/TrEMBL

E7ENM8

Related

ENSP00000414629.2, ENST00000414248.6

Conserved Domains (3) summary

cd05084
Location:436 → 687

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:433 → 686

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:7 → 181

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_002005.4 → NP_001996.1 tyrosine-protein kinase Fes/Fps isoform 1

See identical proteins and their annotated locations for NP_001996.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC124248, X52192

Consensus CDS

CCDS10365.1

UniProtKB/Swiss-Prot

B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5

UniProtKB/TrEMBL

B4DUD9

Related

ENSP00000331504.3, ENST00000328850.8

Conserved Domains (4) summary

cd07685
Location:7 → 239

F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase

cd10361
Location:453 → 537

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cd05084
Location:564 → 815

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:561 → 814

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

90884504..90895776

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017022009.3 → XP_016877498.1 tyrosine-protein kinase Fes/Fps isoform X1

UniProtKB/Swiss-Prot

B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5

UniProtKB/TrEMBL

B4DUD9

Conserved Domains (4) summary

cd07685
Location:7 → 239

F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase

cd10361
Location:453 → 537

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cd05084
Location:564 → 815

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:561 → 814

Pkinase_Tyr; Protein tyrosine kinase
XM_047432235.1 → XP_047288191.1 tyrosine-protein kinase Fes/Fps isoform X3
XM_017022010.2 → XP_016877499.1 tyrosine-protein kinase Fes/Fps isoform X2

UniProtKB/TrEMBL

B4DUD9

Conserved Domains (4) summary

cd10361
Location:395 → 479

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cd05084
Location:506 → 757

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:503 → 756

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:7 → 181

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_047432237.1 → XP_047288193.1 tyrosine-protein kinase Fes/Fps isoform X4
XM_047432233.1 → XP_047288189.1 tyrosine-protein kinase Fes/Fps isoform X1

UniProtKB/Swiss-Prot

B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
XM_047432234.1 → XP_047288190.1 tyrosine-protein kinase Fes/Fps isoform X2
XM_005254882.3 → XP_005254939.1 tyrosine-protein kinase Fes/Fps isoform X3

See identical proteins and their annotated locations for XP_005254939.1

UniProtKB/TrEMBL

B4DUD9

Conserved Domains (3) summary

cd05084
Location:494 → 745

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:491 → 744

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:7 → 239

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_005254880.2 → XP_005254937.1 tyrosine-protein kinase Fes/Fps isoform X2

See identical proteins and their annotated locations for XP_005254937.1

UniProtKB/TrEMBL

B4DUD9

Conserved Domains (4) summary

cd10361
Location:395 → 479

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cd05084
Location:506 → 757

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:503 → 756

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:7 → 181

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_017022005.2 → XP_016877494.1 tyrosine-protein kinase Fes/Fps isoform X1

UniProtKB/Swiss-Prot

B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5

UniProtKB/TrEMBL

B4DUD9

Conserved Domains (4) summary

cd07685
Location:7 → 239

F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase

cd10361
Location:453 → 537

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cd05084
Location:564 → 815

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:561 → 814

Pkinase_Tyr; Protein tyrosine kinase
XM_017022007.2 → XP_016877496.1 tyrosine-protein kinase Fes/Fps isoform X3

UniProtKB/TrEMBL

B4DUD9

Conserved Domains (3) summary

cd05084
Location:494 → 745

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:491 → 744

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:7 → 239

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_017022006.2 → XP_016877495.1 tyrosine-protein kinase Fes/Fps isoform X2

UniProtKB/TrEMBL

B4DUD9

Conserved Domains (4) summary

cd10361
Location:395 → 479

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cd05084
Location:506 → 757

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:503 → 756

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:7 → 181

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_017022008.2 → XP_016877497.1 tyrosine-protein kinase Fes/Fps isoform X4

UniProtKB/TrEMBL

E7ENM8

Conserved Domains (3) summary

cd05084
Location:436 → 687

PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

pfam07714
Location:433 → 686

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:7 → 181

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_047432239.1 → XP_047288195.1 tyrosine-protein kinase Fes/Fps isoform X5

Related

ENSP00000435811.1, ENST00000464684.5
XM_047432236.1 → XP_047288192.1 tyrosine-protein kinase Fes/Fps isoform X5
XM_047432238.1 → XP_047288194.1 tyrosine-protein kinase Fes/Fps isoform X6