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    ima-3 Importin subunit alpha-3 [ Caenorhabditis elegans ]

    Gene ID: 177533, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ima-3
    Official Full Name
    Importin subunit alpha-3
    Primary source
    WormBase:WBGene00002074
    Locus tag
    CELE_F32E10.4
    See related
    AllianceGenome:WB:WBGene00002074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in several processes, including NLS-bearing protein import into nucleus; nuclear pore organization; and positive regulation of axon extension involved in regeneration. Located in cytoplasm and nuclear envelope. Part of nuclear pore. Is expressed in several structures, including germ line; gonad; intestine; muscle cell; and pharynx. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3) and KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ima-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (7558726..7561664, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Early nodulin-75-like Neighboring gene BACK domain-containing protein Neighboring gene Phosphatidylinositol-glycan biosynthesis class F protein Neighboring gene Nitrogen permease regulator 2 Neighboring gene TPR_REGION domain-containing protein Neighboring gene Low-density lipoprotein receptor domain class A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formulation of Chromatin Mobility as a Function of Nuclear Size during C. elegans Embryogenesis Using Polymer Physics Theories. Yesbolatova AK, et al. Phys Rev Lett, 2022 Apr 29. PMID 35570447
    2. Ca(2+)/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation. Ippolito D, et al. Elife, 2021 Nov 12. PMID 34766550, Free PMC Article
    3. Inverse size scaling of the nucleolus by a concentration-dependent phase transition. Weber SC, et al. Curr Biol, 2015 Mar 2. PMID 25702583, Free PMC Article
    4. Size scaling of nucleolus in Caenorhabditis elegans embryos. Ma TH, et al. Biomed J, 2018 Oct. PMID 30580798, Free PMC Article
    5. Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor. Ippolito D, et al. Elife, 2023 May 11. PMID 37166173, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear import signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NLS-bearing protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axon extension involved in regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Importin subunit alpha-3
    NP_501227.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7558726..7561664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068826.6 → NP_501227.1  Importin subunit alpha-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501227.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44925, Q19969
      UniProtKB/TrEMBL
      Q71VM3
      Conserved Domains (5) summary
      COG5064
      Location:19 → 513
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:102 → 222
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:4 → 87
      IBB; Importin beta binding domain
      sd00044
      Location:65 → 92
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:103 → 135
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19969.2

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