Tram2 translocating chain-associating membrane protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tram2provided by MGI
Official Full Name: translocating chain-associating membrane protein 2provided by MGI
Primary source: MGI:MGI:1924817
See related: Ensembl:ENSMUSG00000041779 AllianceGenome:MGI:1924817
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C330003D03Rik
Summary: Predicted to be involved in collagen biosynthetic process and protein insertion into ER membrane. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in nose and skeleton. Orthologous to human TRAM2 (translocation associated membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 9.3), testis adult (RPKM 8.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A4; 1 6.5 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (21071621..21149449, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (21001397..21079225, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2.
Title: Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2.
TRAM2, as a part of the translocon, is required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon
Title: TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

12.MMHAP31FLD3.seq (e-PCR)
- UniSTS:123112

D1Mit4 (e-PCR), detects polymorphism
- UniSTS:128761

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IEA Inferred from Electronic Annotation more info
involved_in collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: translocating chain-associated membrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177409.3 → NP_803128.1 translocating chain-associated membrane protein 2

See identical proteins and their annotated locations for NP_803128.1

Status: PROVISIONAL

Source sequence(s)

AK082751

Consensus CDS

CCDS14846.1

UniProtKB/Swiss-Prot

Q924Z5

Related

ENSMUSP00000047992.5, ENSMUST00000037998.6

Conserved Domains (2) summary

smart00724
Location:112 → 321

TLC; TRAM, LAG1 and CLN8 homology domains

pfam08390
Location:49 → 110

TRAM1; TRAM1-like protein