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    LOC102724428 salt inducible kinase 1B (putative) [ Homo sapiens (human) ]

    Gene ID: 102724428, updated on 18-Sep-2024

    Summary

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    Gene symbol
    LOC102724428
    Gene description
    salt inducible kinase 1B (putative)
    See related
    Ensembl:ENSG00000275993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIK; SIK1; SIK-1; SIK1B; SNF1LK
    Annotation information
    Note: GeneID:102724428 is on a scaffold that is thought to be a false duplication and thus this gene is likely redundant with GeneID:150094. [11 Jun 2021]
    Expression
    Ubiquitous expression in adrenal (RPKM 33.0), liver (RPKM 26.8) and 25 other tissues See more
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    Genomic context

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    See LOC102724428 in Genome Data Viewer
    Location:
    21p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (6111131..6123778)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1669 Neighboring gene uncharacterized LOC102724370 Neighboring gene uncharacterized CH507-42P11.6 Neighboring gene uncharacterized LOC107987288 Neighboring gene uncharacterized LOC124905049

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000021.9 Chromosome 21 Reference GRCh38.p14 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ00263, MGC33415

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative serine/threonine-protein kinase SIK1B
    Names
    Salt-inducible kinase 1
    Serine/threonine-protein kinase SNF1-like kinase 1
    Serine/threonine-protein kinase SNF1LK
    probable serine/threonine-protein kinase SIK1B
    salt-inducible kinase 1B
    serine/threonine-protein kinase SIK1
    NP_001307572.1
    XP_016883697.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320643.3 → NP_001307572.1  putative serine/threonine-protein kinase SIK1B

      Status: VALIDATED

      Source sequence(s)
      AK131076, AW207331, BC038504, CU639417, HY023884
      UniProtKB/Swiss-Prot
      A0A0B4J2F2
      Related
      ENST00000613488.3
      Conserved Domains (2) summary
      cd14408
      Location:300 → 349
      UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
      cd14071
      Location:26 → 278
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      6111131..6123778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028208.2 → XP_016883697.1  putative serine/threonine-protein kinase SIK1B isoform X1

      Conserved Domains (1) summary
      cd14071
      Location:26 → 278
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4J2F2.1 GenPept UniProtKB/Swiss-Prot:A0A0B4J2F2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials