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    tafa5a TAFA chemokine like family member 5a [ Danio rerio (zebrafish) ]

    Gene ID: 100002919, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tafa5aprovided by ZNC
    Official Full Name
    TAFA chemokine like family member 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-344
    See related
    Ensembl:ENSDARG00000069160 AllianceGenome:ZFIN:ZDB-GENE-041210-344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sam5a; fam19a5; fam19a5a; si:dkey-200m9.1; si:dkey-27f18.1; si:dkey-164m14.8
    Summary
    Predicted to enable G protein-coupled receptor binding activity and receptor ligand activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in brain. Orthologous to human TAFA5 (TAFA chemokine like family member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tafa5a in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (27251865..27399210, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (27262231..27409906, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene bromodomain containing 1a Neighboring gene uncharacterized LOC137491561 Neighboring gene TBC1 domain family, member 22a Neighboring gene ceramide kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. FAM19A5l Affects Mustard Oil-Induced Peripheral Nociception in Zebrafish. Jeong I, et al. Mol Neurobiol, 2021 Sep. PMID 34176096
    2. Targeted knockout of a chemokine-like gene increases anxiety and fear responses. Choi JH, et al. Proc Natl Acad Sci U S A, 2018 Jan 30. PMID 29339520, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chemokine-like protein TAFA-5a
    Names
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
    family with sequence similarity 19 member A5, C-C motif chemokine like a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430368.1 → NP_001417297.1  chemokine-like protein TAFA-5a isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX649406, BX901914, CR751234
      UniProtKB/TrEMBL
      A0A2R8QIB8, A0A8M2BFW6
      Related
      ENSDARP00000125559.1, ENSDART00000142117.4

    2. NM_001430369.1 → NP_001417298.1  chemokine-like protein TAFA-5a isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX901914, CR751234
      UniProtKB/TrEMBL
      A0A8M2BGH3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      27251865..27399210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168536.5 → XP_005168593.1  chemokine-like protein TAFA-5a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFV2, H0WEJ8
      Related
      ENSDARP00000125276.1, ENSDART00000150553.2
      Conserved Domains (1) summary
      pfam12020
      Location:42 → 131
      TAFA; TAFA family

    2. XM_005168537.5 → XP_005168594.1  chemokine-like protein TAFA-5a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BFV3, A2BIC8
      Related
      ENSDARP00000114783.1, ENSDART00000145806.3
      Conserved Domains (1) summary
      pfam12020
      Location:41 → 130
      TAFA; TAFA family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394558.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      201697..300731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001122744.1: Suppressed sequence

      Description
      NM_001122744.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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