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    trpR DNA-binding transcriptional repressor TrpR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948917, updated on 10-Oct-2024

    Summary

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    Official Symbol
    trpR
    Official Full Name
    DNA-binding transcriptional repressor TrpR
    Primary source
    ECOCYC:EG11029
    Locus tag
    b4393
    See related
    ASAP:ABE-0014408
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4385; rtrY
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    Genomic context

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    Sequence:
    NC_000913.3 (4632760..4633086)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene energy-dependent translational throttle protein EttA Neighboring gene soluble lytic murein transglycosylase Neighboring gene inosine/xanthosine triphosphatase Neighboring gene putative phosphatase Neighboring gene DNA-binding transcriptional dual regulator Rob

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tandem binding in crystals of a trp repressor/operator half-site complex. Lawson CL, et al. Nature, 1993 Nov 11. PMID 8232559
    2. The solution structures of Escherichia coli trp repressor and trp aporepressor at an intermediate resolution. Arrowsmith C, et al. Eur J Biochem, 1991 Nov 15. PMID 1935980
    3. Fluorescence quenching studies of Trp repressor-operator interaction. Blicharska Z, et al. J Protein Chem, 1999 Nov. PMID 10839618
    4. Mutational analysis of the NH2-terminal arms of the trp repressor indicates a multifunctional domain. Mackintosh SG, et al. Mol Microbiol, 1998 Mar. PMID 9570398
    5. Purification and characterization of trp aporepressor. Joachimiak A, et al. Proc Natl Acad Sci U S A, 1983 Feb. PMID 6338493, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
      Title: An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
    2. Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
      Title: Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
    3. Multiple helical conformations of the helix-turn-helix region have been revealed by Nuclear Overhauser effect -restrained molecular dynamics simulations of tryptophan aporepressor, TrpR.
      Title: Multiple helical conformations of the helix-turn-helix region revealed by NOE-restrained MD simulations of tryptophan aporepressor, TrpR.
    4. Internal dynamics of the tryptophan repressor (TrpR) and two functionally distinct TrpR variants, L75F-TrpR and A77V-TrpR, in their l-Trp-bound forms.
      Title: Internal dynamics of the tryptophan repressor (TrpR) and two functionally distinct TrpR variants, L75F-TrpR and A77V-TrpR, in their l-Trp-bound forms.
    5. N-terminus verified by Edman degradation on mature peptide
      Title: Nucleotide sequence and expression of Escherichia coli trpR, the structural gene for the trp aporepressor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor TrpR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4632760..4633086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418810.1 DNA-binding transcriptional repressor TrpR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418810.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2Y0NE33, A0A7U9QKC1, A0AAN4TX47, A0AAQ1TAG5
      Conserved Domains (1) summary
      COG2973
      Location:6 → 108
      TrpR; Trp operon repressor [Transcription]
    Nucleotide Protein
    Heading Accession and Version

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