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    lacA galactoside O-acetyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945674, updated on 2-May-2024

    Summary

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    Gene symbol
    lacA
    Gene description
    galactoside O-acetyltransferase
    Primary source
    ASAP:ABE-0001177
    Locus tag
    b0342
    See related
    ECOCYC:EG10524
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0339
    Summary
    LacA contains 8 hexapeptide repeats. [More information is available at EcoGene: EG10524]. Early work done on the protein identified it as a homodimer, however recent work has shown it to be a homotrimer. [More information is available at EcoCyc: EG10524].
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    Genomic context

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    Sequence:
    NC_000913.3 (361249..361860, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cyanase Neighboring gene cyanate transporter Neighboring gene lactose permease Neighboring gene beta-galactosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coarse-graining the self-assembly of beta-helical protein building blocks. Curcó D, et al. J Phys Chem B, 2007 Dec 20. PMID 18027921
    2. Testing beta-helix terminal coils stability by targeted substitutions with non-proteogenic amino acids: a molecular dynamics study. Zanuy D, et al. J Struct Biol, 2007 Nov. PMID 17897839
    3. Tyrosine83 is essential for the activity of E. coli galactoside transacetylase. Radeghieri A, et al. Biochim Biophys Acta, 2007 Feb. PMID 17208523
    4. De novo tubular nanostructure design based on self-assembly of beta-helical protein motifs. Haspel N, et al. Structure, 2006 Jul. PMID 16843895
    5. CRYSTALLINE THIOGALACTOSIDE TRANSACETYLASE. ZABIN I. J Biol Chem, 1963 Oct. PMID 14085376

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: The amino acid sequence of thiogalactoside transacetylase of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactoside O-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactoside O-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactoside O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lactose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    galactoside O-acetyltransferase
    NP_414876.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      361249..361860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414876.1 galactoside O-acetyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414876.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A140NFL4
      Conserved Domains (1) summary
      PRK09527
      Location:1 → 203
      lacA; galactoside O-acetyltransferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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