LecRK-I.9 Concanavalin A-like lectin protein kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: LecRK-I.9
Gene description: Concanavalin A-like lectin protein kinase family protein
Primary source: Araport:AT5G60300
Locus tag: AT5G60300
See related: TAIR:AT5G60300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Does not Respond to Nucleotides 1; DORN1; F15L12.17; F15L12_17; L-type lectin receptor kinase I.9; lectin receptor kinase I.9
Summary: Lectin Receptor Kinase involved in protein-protein interactions with RGD-containing proteins as potential ligands. Role in cell wall-plasma membrane adhesion. Involved in Phytophthora resistance.
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Genomic context

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See LecRK-I.9 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 3

Sequence:: Chromosome: 5; NC_003076.8 (24264488..24268029)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap4A) in Arabidopsis thaliana.
Title: The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap(4)A) in Arabidopsis thaliana.
S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis.
Title: S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis.
Mutation of DORN1 phosphorylation sites on RBOHD eliminates the ability of ATP to induce stomatal closure. The data implicate purinergic signaling via DORN1 in the control of stomatal aperture.
Title: Extracellular ATP elicits DORN1-mediated RBOHD phosphorylation to regulate stomatal aperture.
The role of LecRK-I.9 is discussed with regard to the potential molecular mechanisms linking jasmonic acid signalling to cell wall damage and/or extracellular ATP perception.
Title: The Arabidopsis thaliana lectin receptor kinase LecRK-I.9 is required for full resistance to Pseudomonas syringae and affects jasmonate signalling.
X-ray crystallographic studies of the extracellular domain of the first plant ATP receptor, DORN1, and the orthologous protein from Camelina sativa, have been presented.
Title: X-ray crystallographic studies of the extracellular domain of the first plant ATP receptor, DORN1, and the orthologous protein from Camelina sativa.
the genetic and biochemical evidence for the role of DORN1 in extracellular ATP signalling, placing this within the wider context of extracellular ATP signalling during plant stress responses. [Review]
Title: Extracellular ATP, a danger signal, is recognized by DORN1 in Arabidopsis.
LecRK-I.9 insertion mutants gain susceptibility to Phytophthora. Overexpression enhances resistance. Observations strongly suggest that LecRK-I.9 plays a role in disease resistance by stabilizing the cell wall-plasma membrane continuum. [LecRK-I.9]
Title: The lectin receptor kinase LecRK-I.9 is a novel Phytophthora resistance component and a potential host target for a RXLR effector.
DORN1 is essential for perception of extracellular ATP and likely plays a variety of roles in plant stress resistance.
Title: Identification of a plant receptor for extracellular ATP.
The lectin receptor kinase encoded by At5g60300 is involved in protein-protein interactions with RGD-containing proteins as potential ligands, and may play a structural and signaling role at the plant cell surfaces.
Title: Lectin receptor kinases participate in protein-protein interactions to mediate plasma membrane-cell wall adhesions in Arabidopsis.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001085304.1

Supported by ESTs:

NM_125423.3

Supported by ESTs:

NM_180899.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to ATP	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to oomycetes	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to oomycetes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to oomycetes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular ATP signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of jasmonic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Concanavalin A-like lectin protein kinase family protein

NP_001078773.1

Concanavalin A-like lectin protein kinase family protein; FUNCTIONS IN: carbohydrate binding, kinase activity; INVOLVED IN: focal adhesion assembly; LOCATED IN: plasma membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Legume lectin, beta chain (InterPro:IPR001220), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Concanavalin A-like lectin/glucanase, subgroup (InterPro:IPR013320), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Legume lectin, beta chain, Mn/Ca-binding site (InterPro:IPR019825); BEST Arabidopsis thaliana protein match is: Concanavalin A-like lectin protein kinase family protein (TAIR:AT3G45430.1); Has 112043 Blast hits to 110768 proteins in 4079 species: Archae - 91; Bacteria - 12985; Metazoa - 40494; Fungi - 8927; Plants - 33308; Viruses - 365; Other Eukaryotes - 15873 (source: NCBI BLink).

NP_200838.1

Concanavalin A-like lectin protein kinase family protein; FUNCTIONS IN: carbohydrate binding, kinase activity; INVOLVED IN: focal adhesion assembly; LOCATED IN: plasma membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Legume lectin, beta chain (InterPro:IPR001220), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Concanavalin A-like lectin/glucanase, subgroup (InterPro:IPR013320), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Legume lectin, beta chain, Mn/Ca-binding site (InterPro:IPR019825); BEST Arabidopsis thaliana protein match is: Concanavalin A-like lectin protein kinase family protein (TAIR:AT3G45430.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NP_851230.1

Concanavalin A-like lectin protein kinase family protein; FUNCTIONS IN: carbohydrate binding, kinase activity; INVOLVED IN: focal adhesion assembly; LOCATED IN: plasma membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Legume lectin, beta chain (InterPro:IPR001220), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Concanavalin A-like lectin/glucanase, subgroup (InterPro:IPR013320), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Concanavalin A-like lectin/glucanase (InterPro:IPR008985), Legume lectin, beta chain, Mn/Ca-binding site (InterPro:IPR019825); BEST Arabidopsis thaliana protein match is: Concanavalin A-like lectin protein kinase family protein (TAIR:AT3G45430.1); Has 112358 Blast hits to 111080 proteins in 4130 species: Archae - 91; Bacteria - 13102; Metazoa - 40494; Fungi - 9266; Plants - 33404; Viruses - 365; Other Eukaryotes - 15636 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24264488..24268029

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125423.3 → NP_200838.1 Concanavalin A-like lectin protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200838.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178U778, A0A654GCR0

Conserved Domains (2) summary

cd14066
Location:350 → 614

STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs

pfam00139
Location:24 → 274

Lectin_legB; Legume lectin domain
NM_001085304.1 → NP_001078773.1 Concanavalin A-like lectin protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078773.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q56XH0, Q93ZR5, Q9LSR8

UniProtKB/TrEMBL

A0A178U778

Conserved Domains (3) summary

smart00220
Location:344 → 608

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14066
Location:350 → 614

STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs

pfam00139
Location:24 → 274

Lectin_legB; Legume lectin domain
NM_180899.2 → NP_851230.1 Concanavalin A-like lectin protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_851230.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178U778, A0A654GCR0

Conserved Domains (2) summary

cd14066
Location:350 → 614

STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs

pfam00139
Location:24 → 274

Lectin_legB; Legume lectin domain