U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LAP lingual antimicrobial peptide [ Bos taurus (cattle) ]

    Gene ID: 403090, updated on 6-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    LAP
    Gene description
    lingual antimicrobial peptide
    See related
    BGD:BT11785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LAP in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (6234006..6235870)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene 5.8S ribosomal RNA Neighboring gene 18S ribosomal RNA Neighboring gene beta-defensin-like Neighboring gene lingual antimicrobial peptide-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Existence of functional lingual antimicrobial peptide in bovine milk. Isobe N, et al. J Dairy Sci, 2009 Jun. PMID 19448002
    2. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Russell JP, et al. Infect Immun, 1996 May. PMID 8613361, Free PMC Article
    3. Epithelial antibiotics induced at sites of inflammation. Schonwetter BS, et al. Science, 1995 Mar 17. PMID 7886453
    4. Expression of antimicrobial peptides by bovine endothelial cells. Alva-Murillo N, et al. Cell Immunol, 2012 Nov. PMID 23298865
    5. The role of oct-1 in the regulation of tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP) expression in bovine mammary epithelial cells. Yang J, et al. Immunogenetics, 2011 Nov. PMID 21674298

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stimulation of umbilical-vein endothelial cells with S. aureus or LPS induced the expression of lingual antimicrobial peptide. This expression was regulated by the autocrine production of tumor necrosis factor-alpha.
      Title: Expression of antimicrobial peptides by bovine endothelial cells.
    2. The results from this study clearly demonstrate the involvement of octamer transcription factor-1 in the regulation of tracheal antimicrobial peptide and lingual antimicrobial peptide expression.
      Title: The role of oct-1 in the regulation of tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP) expression in bovine mammary epithelial cells.
    3. The role of NF-kappaB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
      Title: Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cells.
    4. LAP was detected in the eluate by competitive enzyme immunoassay and had antimicrobial activity against E. coli
      Title: Existence of functional lingual antimicrobial peptide in bovine milk.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables CCR6 chemokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chemoattractant activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    lingual antimicrobial peptide
    Names
    LAP-related prepropeptide

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203435.4 → NP_982259.3  lingual antimicrobial peptide precursor

      Status: PROVISIONAL

      Source sequence(s)
      AY911374
      UniProtKB/Swiss-Prot
      Q28202, Q28880, Q56JV8
      UniProtKB/TrEMBL
      A0AAA9U0J6
      Conserved Domains (1) summary
      pfam00711
      Location:28 → 62
      Defensin_beta; Beta defensin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      6234006..6235870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28880.1 GenPept UniProtKB/Swiss-Prot:Q28880

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials