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    THA1P threonine aldolase 1, pseudogene [ Homo sapiens (human) ]

    Gene ID: 390816, updated on 17-Sep-2024

    Summary

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    Official Symbol
    THA1Pprovided by HGNC
    Official Full Name
    threonine aldolase 1, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:18004
    See related
    AllianceGenome:HGNC:18004
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLY1
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    Genomic context

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    See THA1P in Genome Data Viewer
    Location:
    17q25.3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78248590..78256185, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79142679..79150294, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76244671..76252266, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76210079-76210980 Neighboring gene baculoviral IAP repeat containing 5 Neighboring gene MPRA-validated peak3015 silencer Neighboring gene transmembrane protein 235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12882 Neighboring gene MPRA-validated peak3016 silencer Neighboring gene uncharacterized LOC105371910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76246144-76246789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12883 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76249484-76250202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76250203-76250920 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12886 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5435 Neighboring gene long intergenic non-protein coding RNA 1993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76263321-76264044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76264045-76264770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76266221-76266945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76268313-76269002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76273439-76274272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76274273-76275106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76283739-76284240 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:76287812-76288081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76297857-76298375 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:76304459-76304681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76311214-76311972 Neighboring gene uncharacterized LOC105371912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12890 Neighboring gene Sharpr-MPRA regulatory region 775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76318420-76318963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76320051-76320592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76320593-76321136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76321137-76321678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76338363-76338868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76340895-76341399

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene. Edgar AJ. BMC Genomics, 2005 Mar 9. PMID 15757516, Free PMC Article
    2. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. Zhang ZD, et al. Genome Biol, 2010. PMID 20210993, Free PMC Article
    3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mice, the western-clawed frog and the zebrafish have transcribed threonine aldolase/GLY1 genes, but the human homolog is a non-transcribed pseudogene
      Title: Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009023.3 

      Range
      101..7696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      78248590..78256185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      79142679..79150294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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