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    wc-1 white collar-1 [ Neurospora crassa OR74A ]

    Gene ID: 3875924, updated on 6-Jun-2024

    Summary

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    Gene symbol
    wc-1
    Gene description
    white collar-1
    Locus tag
    NCU02356
    See related
    FungiDB:NCU02356; VEuPathDB:NCU02356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Neurospora crassa OR74A (strain: OR74A)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora
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    Genomic context

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    See wc-1 in Genome Data Viewer
    Location:
    other: VII
    Exon count:
    2
    Sequence:
    Chromosome: VII; NC_026507.1 (2767393..2773846)

    Linkage Group VII - NC_026507.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene SDS23 Neighboring gene importin subunit beta-3 Neighboring gene hypothetical protein Neighboring gene porin-binding domain protein-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_026507.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Light-independent phosphorylation of WHITE COLLAR-1 regulates its function in the Neurospora circadian negative feedback loop. He Q, et al. J Biol Chem, 2005 Apr 29. PMID 15731099
    2. The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora. Wang B, et al. Mol Cell, 2019 May 16. PMID 30954403, Free PMC Article
    3. Alternative Use of DNA Binding Domains by the Neurospora White Collar Complex Dictates Circadian Regulation and Light Responses. Wang B, et al. Mol Cell Biol, 2015 Dec 28. PMID 26711258, Free PMC Article
    4. Biological Significance of Photoreceptor Photocycle Length: VIVID Photocycle Governs the Dynamic VIVID-White Collar Complex Pool Mediating Photo-adaptation and Response to Changes in Light Intensity. Dasgupta A, et al. PLoS Genet, 2015 May. PMID 25978382, Free PMC Article
    5. The Ccr4-not protein complex regulates the phase of the Neurospora circadian clock by controlling white collar protein stability and activity. Huang G, et al. J Biol Chem, 2013 Oct 25. PMID 24030828, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We report mapping of 80 phosphosites on WC-1 and 15 on WC-2 and elucidation of the time-of-day-specific code, requiring both a group of phosphoevents on WC-1 and two distinct clusters on WC-2, that governs circadian repression, leading to feedback loop closure.
      Title: The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora.
    2. DNA binding for light induction by the White Collar complex requires only WC-2, whereas DNA binding for circadian functions requires WC-2 .
      Title: Alternative Use of DNA Binding Domains by the Neurospora White Collar Complex Dictates Circadian Regulation and Light Responses.
    3. WC-1 stability is reduced in the fastest photocycle mutant even in the presence of clock gene frequency as a second stabilizing factor.
      Title: Biological Significance of Photoreceptor Photocycle Length: VIVID Photocycle Governs the Dynamic VIVID-White Collar Complex Pool Mediating Photo-adaptation and Response to Changes in Light Intensity.
    4. Our data suggest that WCC acts as a general switch for light-induced chromatin remodeling and gene expression. SUB1 and FF7 synergistically determine the extent of light-induction of target genes in common with WCC( WC1 and WC2)
      Title: Combinatorial control of light induced chromatin remodeling and gene activation in Neurospora.
    5. The not1 transcript displays a circadian oscillation with a similar phase as frq. Down-regulation of not1 leads to low levels of WC-1 and WC-2 and a delayed circadian phase as a result of increased protein degradation and increased WC activity.
      Title: The Ccr4-not protein complex regulates the phase of the Neurospora circadian clock by controlling white collar protein stability and activity.
    6. A WC-1/NGF-1 complex is preassembled in the dark on light-inducible promoters that, after exposure to light stimulation, leads to histone H3 acetylation and transcriptional activation.
      Title: Physical association of the WC-1 photoreceptor and the histone acetyltransferase NGF-1 is required for blue light signal transduction in Neurospora crassa.
    7. WC-1, part of White Collar Complex (WCC), and VVD contain a flavin-binding light-oxygen-voltage (LOV) domain; VVD-mediated desensitization and stabilization of the light activated WCC explain how Neurospora can robustly entrain photoperiods.
      Title: Photoadaptation in Neurospora by competitive interaction of activating and inhibitory LOV domains.
    8. Data show that WC-1 stability cycles, that WC-1 is stable in the absence of FRQ, and that physical binding between FRQ and WCC is essential for closure of the negative feedback loop.
      Title: Closing the circadian negative feedback loop: FRQ-dependent clearance of WC-1 from the nucleus.
    9. a common mechanism controls the light-induced transcription of immediate early genes (such as frq, al-3, and vvd) in Neurospora, in which light induces the binding of identical large WC-1/WC-2 complexes to the light response elements in their promoters
      Title: Molecular mechanism of light responses in Neurospora: from light-induced transcription to photoadaptation.
    10. Light sensitivity and temperature compensation may be conferred by the intact FRQ/WC loop in the WT strain.
      Title: Circadian clock genes frequency and white collar-1 are not essential for entrainment to temperature cycles in Neurospora crassa.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Names
    white collar 1 protein
    white collar 1 protein, variant 1
    white collar 1 protein, variant 2
    white collar 1 protein, variant 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_026507.1 Reference assembly

      Range
      2767393..2773846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011396849.1 → XP_011395151.1  white collar 1 protein [Neurospora crassa OR74A]

      See identical proteins and their annotated locations for XP_011395151.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q01371, Q7RVA7, V5IKL6
      Conserved Domains (5) summary
      smart00401
      Location:929 → 980
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00130
      Location:585 → 684
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd00202
      Location:934 → 987
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam00989
      Location:581 → 684
      PAS; PAS fold
      pfam13426
      Location:390 → 507
      PAS_9; PAS domain

    2. XM_011396850.1 → XP_011395152.1  white collar 1 protein, variant 1 [Neurospora crassa OR74A]

      See identical proteins and their annotated locations for XP_011395152.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q01371, Q7RVA7, V5IKL6
      Conserved Domains (5) summary
      smart00401
      Location:929 → 980
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00130
      Location:585 → 684
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd00202
      Location:934 → 987
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam00989
      Location:581 → 684
      PAS; PAS fold
      pfam13426
      Location:390 → 507
      PAS_9; PAS domain

    3. XM_011396851.1 → XP_011395153.1  white collar 1 protein, variant 3 [Neurospora crassa OR74A]

      See identical proteins and their annotated locations for XP_011395153.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q01371, Q7RVA7, V5IKL6
      Conserved Domains (5) summary
      smart00401
      Location:929 → 980
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00130
      Location:585 → 684
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd00202
      Location:934 → 987
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam00989
      Location:581 → 684
      PAS; PAS fold
      pfam13426
      Location:390 → 507
      PAS_9; PAS domain

    4. XM_011396848.1 → XP_011395150.1  white collar 1 protein, variant 2 [Neurospora crassa OR74A]

      See identical proteins and their annotated locations for XP_011395150.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q01371, Q7RVA7, V5IKL6
      Conserved Domains (5) summary
      smart00401
      Location:929 → 980
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00130
      Location:585 → 684
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd00202
      Location:934 → 987
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam00989
      Location:581 → 684
      PAS; PAS fold
      pfam13426
      Location:390 → 507
      PAS_9; PAS domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01371.2

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