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    IL10RA interleukin 10 receptor subunit alpha [ Homo sapiens (human) ]

    Gene ID: 3587, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IL10RAprovided by HGNC
    Official Full Name
    interleukin 10 receptor subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:5964
    See related
    Ensembl:ENSG00000110324 MIM:146933; AllianceGenome:HGNC:5964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1
    Summary
    The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
    Expression
    Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL10RA in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (117986394..118003037)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118002773..118019416)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117857109..117873752)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FXYD6-FXYD2 readthrough Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:117712427-117713626 Neighboring gene FXYD6 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117726457-117726957 Neighboring gene FXYD domain containing ion transport regulator 6 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:117738498-117739697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:117740007-117740526 Neighboring gene Sharpr-MPRA regulatory region 1172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117778029-117778529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117784655-117785647 Neighboring gene transmembrane serine protease 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117802800-117803339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117803340-117803878 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19102 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:117843533-117843947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5580 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117869597-117870098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117881450-117881950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5581 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19207 Neighboring gene small integral membrane protein 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117935307-117935808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117947648-117948243 Neighboring gene RNA, 7SL, cytoplasmic 828, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13014 Neighboring gene uncharacterized LOC105369517 Neighboring gene transmembrane serine protease 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation. Murugan D, et al. J Clin Immunol, 2014 Apr. PMID 24519095
    2. Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients. Ben Fredj N, et al. APMIS, 2017 May. PMID 28225209
    3. Genetic variant of IL-10RA and susceptibility to rheumatoid arthritis in a Chinese population. Yang XK, et al. Clin Rheumatol, 2017 Apr. PMID 27796662
    4. The IL-10R1 S138G loss-of-function allele and ulcerative colitis. Grundtner P, et al. Genes Immun, 2009 Jan. PMID 18800073
    5. Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements. Lai CF, et al. J Biol Chem, 1996 Jun 14. PMID 8662928

    See all (155) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
      Title: Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
    2. Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity.
      Title: Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity.
    3. IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
      Title: IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
    4. Characterization of novel and large fragment deletions in exon 1 of the IL10RA gene in Chinese children with very early onset inflammatory bowel diseases.
      Title: Characterization of novel and large fragment deletions in exon 1 of the IL10RA gene in Chinese children with very early onset inflammatory bowel diseases.
    5. Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations.
      Title: Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations.
    6. IL-10 suppresses IFN-gamma-mediated signaling in lung adenocarcinoma.
      Title: IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
    7. [Relationship between gene polymorphism at rs2228055 locus in the exon region of interleukin-10 receptor A and susceptibility to food allergy in children].
      Title: [Relationship between gene polymorphism at rs2228055 locus in the exon region of interleukin-10 receptor A and susceptibility to food allergy in children].
    8. Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27.
      Title: Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27.
    9. Erythema Nodosum Leprosum Neutrophil Subset Expressing IL-10R1 Transmigrates into Skin Lesions and Responds to IL-10.
      Title: Erythema Nodosum Leprosum Neutrophil Subset Expressing IL-10R1 Transmigrates into Skin Lesions and Responds to IL-10.
    10. Two SNPs, rs3024490 and rs1800871, were found to be significantly different between breast cancer patients and healthy women. These SNPs also increased the risk of breast cancer in co-dominant and dominant models. Another SNP, rs1554286, was significantly associated with an increased risk of breast cancer in the co-dominant model.
      Title: The effect of interleukin 10 polymorphisms on breast cancer susceptibility in Han women in Shaanxi Province.
    Submit: New GeneRIF Correction See all GeneRIFs (81)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Inflammatory bowel disease 28
    MedGen: C2751053 OMIM: 613148 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables interleukin-10 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-10 receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-10-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intestinal epithelial structure maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-10 receptor subunit alpha
    Names
    IL-10 receptor subunit alpha
    IL-10R subunit 1
    IL-10R subunit alpha
    IL-10RA
    interleukin 10 receptor, alpha
    interleukin-10 receptor alpha chain
    interleukin-10 receptor subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016275.1 RefSeqGene

      Range
      5001..20093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_151

    mRNA and Protein(s)

    1. NM_001558.4 → NP_001549.2  interleukin-10 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_001549.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the protein-coding transcript.
      Source sequence(s)
      AK291645, AP002962, BC028082, CA307153
      Consensus CDS
      CCDS8388.1
      UniProtKB/Swiss-Prot
      A8K6I0, B0YJ27, Q13651
      UniProtKB/TrEMBL
      H2DF05
      Related
      ENSP00000227752.4, ENST00000227752.8
      Conserved Domains (2) summary
      pfam01108
      Location:21 → 111
      Tissue_fac; Tissue factor
      cl21522
      Location:129 → 227
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. NR_026691.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate exon compared to variant 1. It is not thought to be protein-coding.
      Source sequence(s)
      AK291645, AK301484, AP002962, BC028082, CA307153

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      117986394..118003037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426882.1 → XP_047282838.1  interleukin-10 receptor subunit alpha isoform X1

    2. XM_047426884.1 → XP_047282840.1  interleukin-10 receptor subunit alpha isoform X3

    3. XM_047426883.1 → XP_047282839.1  interleukin-10 receptor subunit alpha isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      118002773..118019416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368667.1 → XP_054224642.1  interleukin-10 receptor subunit alpha isoform X1

    2. XM_054368669.1 → XP_054224644.1  interleukin-10 receptor subunit alpha isoform X3

    3. XM_054368668.1 → XP_054224643.1  interleukin-10 receptor subunit alpha isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13651.2 GenPept UniProtKB/Swiss-Prot:Q13651

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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