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    IFNT2 interferon tau [ Bos taurus (domestic cattle) ]

    Gene ID: 317698, updated on 4-Oct-2024

    Summary

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    Gene symbol
    IFNT2
    Gene description
    interferon tau
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    IFNT; TP-1; IFNT1; IFN-tau-c2
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    Genomic context

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    See IFNT2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (22608434..22609746, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene interferon tau-3 Neighboring gene interferon tau-like Neighboring gene interferon tau-like Neighboring gene interferon tau c1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of interferon-tau (IFN-tau) gene promoters by growth factors that target the Ets-2 composite enhancer: a possible model for maternal control of IFN-tau production by the conceptus during early pregnancy. Ezashi T, et al. Endocrinology, 2004 Oct. PMID 15217985
    2. Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant? Forde N, et al. Biol Reprod, 2011 Jul. PMID 21349821
    3. Effect of ovine granulocyte-macrophage colony-stimulating factor on bovine in vitro embryo development and blastocyst interferon-τ secretion. Hickman CF, et al. Reprod Domest Anim, 2011 Aug. PMID 20977503
    4. Involvement of GATA transcription factors in the regulation of endogenous bovine interferon-tau gene transcription. Bai H, et al. Mol Reprod Dev, 2009 Dec. PMID 19598245
    5. Is cortisol a modulator of interferon tau action in the endometrium during early pregnancy in cattle? Majewska M, et al. J Reprod Immunol, 2012 Mar. PMID 22361386

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Specific activation of embryonic IFNAR1 and endometrial IFNAR2 induced by embryonic IFNtau directs normal uterine fate for bovine early implantation.
      Title: Specific activation of embryonic IFNAR1 and endometrial IFNAR2 induced by embryonic IFNτ directs normal uterine fate for bovine early implantation.
    2. Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cellsdagger.
      Title: Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells†.
    3. Pregnancy-induced changes in the transcriptome of the bovine corpus luteum during and after embryonic interferon-tau secretiondagger.
      Title: Pregnancy-induced changes in the transcriptome of the bovine corpus luteum during and after embryonic interferon-tau secretion†.
    4. JAK3 and PI3K mediates the suppressive effects of interferon tau on neutrophil extracellular traps formation during peri-implantation period.
      Title: JAK3 and PI3K mediates the suppressive effects of interferon tau on neutrophil extracellular traps formation during peri-implantation period.
    5. Heat stress influences the attenuation of prostaglandin synthesis by interferon tau in bovine endometrial cells.
      Title: Heat stress influences the attenuation of prostaglandin synthesis by interferon tau in bovine endometrial cells.
    6. Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy.
      Title: Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy.
    7. Interferon-Tau Exerts Direct Prosurvival and Antiapoptotic Actions in Luteinized Bovine Granulosa Cells.
      Title: Interferon-Tau Exerts Direct Prosurvival and Antiapoptotic Actions in Luteinized Bovine Granulosa Cells.
    8. Interferon tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus, which may provide immunological tolerance to accept the embryo.
      Title: Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus.
    9. The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
      Title: A transcriptional cofactor YAP regulates IFNT expression via transcription factor TEAD in bovine conceptuses.
    10. Report interferon-tau dependent STAT1 regulation of SOCS genes in bovine endometrium during estrus cycle and embryo implantation.
      Title: Analysis of STAT1 expression and biological activity reveals interferon-tau-dependent STAT1-regulated SOCS genes in the bovine endometrium.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables type I interferon receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in T cell activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in humoral immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in natural killer cell activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon tau-2
    Names
    IFN-tau-1
    IFN-tau-2
    IFN-tau1
    IFN-tau2
    antiluteolysin
    interferon alpha II
    interferon tau-1
    interferon, trophoblast
    interferon-tau1e
    interferon-tau3e
    trophoblast antiluteolytic protein
    trophoblast protein-1
    trophoblast type I interferon
    trophoblastin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015511.4 → NP_001015511.3  interferon tau-2 precursor

      See identical proteins and their annotated locations for NP_001015511.3

      Status: VALIDATED

      Source sequence(s)
      NKLS02000008
      UniProtKB/Swiss-Prot
      P15694, P15696, Q28126, Q28127, Q28128, Q28191, Q95NE2
      Conserved Domains (1) summary
      pfam00143
      Location:26 → 185
      Interferon; Interferon alpha/beta domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22608434..22609746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15696.2 GenPept UniProtKB/Swiss-Prot:P15696
    P56830.1 GenPept UniProtKB/Swiss-Prot:P56830

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials