IFNL3 interferon lambda 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IFNL3provided by HGNC
Official Full Name: interferon lambda 3provided by HGNC
Primary source: HGNC:HGNC:18365
See related: Ensembl:ENSG00000197110 MIM:607402; AllianceGenome:HGNC:18365
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL28B; IL28C; IL-28B; IL-28C; IFN-lambda-3; IFN-lambda-4
Summary: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 19q13.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (39243455..39245250, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (42047720..42049515, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39734095..39735890, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Predictive Potential Of Il28b Gene In Hcv Patients, Resistant To Daclatasvir And Sofosbuvir In KPK Population.
Title: Predictive Potential Of Il28b Gene In Hcv Patients, Resistant To Daclatasvir And Sofosbuvir In KPK Population.
IFN-lambda3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.
Title: IFN-λ3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.
Its all about IFN-lambda4: Protective role of IFNL4 polymorphism against COVID-19-related pneumonia in females.
Title: Its all about IFN-λ4: Protective role of IFNL4 polymorphism against COVID-19-related pneumonia in females.
IFN-lambda3 and CCL17 as predictors of disease progression in patients with mild to moderate COVID-19: A cohort study in a real-world setting.
Title: IFN-λ3 and CCL17 as predictors of disease progression in patients with mild to moderate COVID-19: A cohort study in a real-world setting.
IFNL3/4 polymorphisms as a two-edged sword: An association with COVID-19 outcome.
Title: IFNL3/4 polymorphisms as a two-edged sword: An association with COVID-19 outcome.
The Impact of interferon lambda 3 Polymorphism on Hepato-Cellular Carcinoma Progression in Hepatitis C Virus Patients: Treatment-Naive and Experienced.
Title: The Impact of interferon lambda 3 Polymorphism on Hepato-Cellular Carcinoma Progression in Hepatitis C Virus Patients: Treatment-Naïve and Experienced.
Assessment of serum interleukin-28 as a biomarker to predict mortality in traumatic patients with sepsis.
Title: Assessment of serum interleukin-28 as a biomarker to predict mortality in traumatic patients with sepsis.
IL28B, TLR7 SNPs, and cytomegalovirus infection are risk factors for advanced liver disease in chronic hepatitis C patients.
Title: IL28B, TLR7 SNPs, and cytomegalovirus infection are risk factors for advanced liver disease in chronic hepatitis C patients.
PNPLA3 and IL 28B signature for predicting susceptibility to chronic hepatitis C infection and fibrosis progression.
Title: PNPLA3 and IL 28B signature for predicting susceptibility to chronic hepatitis C infection and fibrosis progression.
The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients.
Title: The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients.

Submit: New GeneRIF Correction See all GeneRIFs (581)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hepatitis C virus, susceptibility to MedGen: C1835407 OMIM: 609532 GeneReviews: Not available	not available
Peginterferon alfa-2a response MedGen: CN184128 GeneReviews: Not available	not available
Peginterferon alfa-2b response MedGen: CN078000 GeneReviews: Not available	not available
Ribavirin response MedGen: CN184129 GeneReviews: Not available	not available
Simeprevir response MedGen: CN236396 GeneReviews: Not available	not available
Telaprevir response MedGen: CN078014 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. EBI GWAS Catalog EBI GWAS CatalogPubMed
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494905

G64446 (e-PCR)
- UniSTS:163899

NoName (e-PCR)
- UniSTS:481139

SHGC-111908 (e-PCR)
- UniSTS:183193

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	NAS Non-traceable Author Statement more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of immune response	IEA Inferred from Electronic Annotation more info
involved_in type III interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interferon lambda-3

Names: cytokine Zcyto22; interferon, lambda 4; interleukin-28B; interleukin-28C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042193.1 RefSeqGene

Range

4722..6517

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1011

mRNA and Protein(s)

NM_001346937.2 → NP_001333866.1 interferon lambda-3 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). This isoform does not contain a signal peptide, compared to isoform 2.

Source sequence(s)

AC011445, AY129149

Consensus CDS

CCDS86765.1

UniProtKB/TrEMBL

A0A0C4DGW8, A0A7H1MG84

Related

ENSP00000481633.1, ENST00000613087.5

Conserved Domains (1) summary

pfam15177
Location:38 → 195

IL28A; Interleukin-28A
NM_172139.4 → NP_742151.2 interferon lambda-3 isoform 2 precursor

See identical proteins and their annotated locations for NP_742151.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate 5' terminal exon resulting in a novel 5' UTR, and the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus, and contains a signal peptide, compared to isoform 1.

Source sequence(s)

AC011445, BC130316

Consensus CDS

CCDS12530.1

UniProtKB/Swiss-Prot

A2BDE1, Q6VN56, Q7Z4J3, Q8IWL6, Q8IZI9

UniProtKB/TrEMBL

A0A7H1MG84, A0A7R8C2Z6

Related

ENSP00000409000.2, ENST00000413851.3

Conserved Domains (1) summary

pfam15177
Location:34 → 191

IL28A; Interleukin-28A