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    DKK2 dickkopf WNT signaling pathway inhibitor 2 [ Homo sapiens (human) ]

    Gene ID: 27123, updated on 2-Nov-2024

    Summary

    Official Symbol
    DKK2provided by HGNC
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 2provided by HGNC
    Primary source
    HGNC:HGNC:2892
    See related
    Ensembl:ENSG00000155011 MIM:605415; AllianceGenome:HGNC:2892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DKK-2
    Summary
    This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lung (RPKM 4.8), ovary (RPKM 3.0) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DKK2 in Genome Data Viewer
    Location:
    4q25
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (106921802..107036313, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (110226876..110341391, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (107842959..107957470, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377356 Neighboring gene ACTR6 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:107898921-107899694 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:107899695-107900466 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:107994239-107994739 Neighboring gene vomeronasal 1 receptor 22 pseudogene Neighboring gene vomeronasal 1 receptor 23 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables co-receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dickkopf-related protein 2
    Names
    dickkopf 2 homolog
    dickkopf homolog 2
    dickkopf-2
    hDkk-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014421.3NP_055236.1  dickkopf-related protein 2 precursor

      See identical proteins and their annotated locations for NP_055236.1

      Status: REVIEWED

      Source sequence(s)
      AF177395, AP001819, AY358414
      Consensus CDS
      CCDS3675.1
      UniProtKB/Swiss-Prot
      A0AVE9, B2R6S7, Q9UBU2, Q9UIU3
      Related
      ENSP00000285311.3, ENST00000285311.8
      Conserved Domains (1) summary
      pfam04706
      Location:78128
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      106921802..107036313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      110226876..110341391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)