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    cII CII-like transcriptional activator [ Escherichia phage Lambda ]

    Gene ID: 2703494, updated on 18-Aug-2023

    Summary

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    Gene symbol
    cII
    Gene description
    CII-like transcriptional activator
    Locus tag
    lambdap59
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia phage Lambda (nat-host: Escherichia coli)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Lambdavirus
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    Genomic context

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    Sequence:
    NC_001416.1 (38360..38653)

    NC_001416.1Genomic Context describing neighboring genes Neighboring gene RexA-like exclusion protein Neighboring gene LexA family transcriptional regulator Neighboring gene Neighboring gene protein-coding Neighboring gene protein-coding Neighboring gene Cro/CI family transcriptional regulator Neighboring gene replication initiation O-like Neighboring gene protein-coding Neighboring gene protein-coding Neighboring gene Neighboring gene DNA replication protein Neighboring gene Ren-like exclusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001416.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of C-terminal residues in oligomerization and stability of lambda CII: implications for lysis-lysogeny decision of the phage. Datta AB, et al. J Mol Biol, 2005 Jan 14. PMID 15571724
    2. Nucleotide-sequence analysis of a chi site. Smith GR, et al. Cold Spring Harb Symp Quant Biol, 1979. PMID 158460
    3. A single base-pair change creates a Chi recombinational hotspot in bacteriophage lambda. Sprague KU, et al. Proc Natl Acad Sci U S A, 1978 Dec. PMID 282634, Free PMC Article
    4. Transcription terminates at lambda tR1 in three clusters. Lau LF, et al. Proc Natl Acad Sci U S A, 1982 Oct. PMID 6216477, Free PMC Article
    5. Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks. Manjanatha MG, et al. Mutat Res Genet Toxicol Environ Mutagen, 2015 Aug. PMID 26232257

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that none of the bacteriophage lambda protein cII mutant frequencies (MFs) measured at any time point was significantly higher than the corresponding control MFs
      Title: Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks.
    2. report the first purification of HflK and HflC separately as active and functional proteins and show that each can interact with HflB on its own and each inhibits the proteolysis of lambdaCII
      Title: Escherichia coli HflK and HflC can individually inhibit the HflB (FtsH)-mediated proteolysis of lambdaCII in vitro.
    3. in the model of CII structure, protein-protein contacts for dimer and tetramer formation are different
      Title: Role of C-terminal residues in oligomerization and stability of lambda CII: implications for lysis-lysogeny decision of the phage.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    regulatory

    • Loc: 38543-38557 regulatory_class = other

    variation

    • Loc: 38364 replace = g
    • Loc: 38370 replace = t
    • Loc: 38371 replace = t
    • Loc: 38376 replace = g
    • Loc: 38379 replace = a
    • Loc: 38380 replace = t
    • Loc: 38430 replace = c

    General protein information

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    Preferred Names
    CII-like transcriptional activator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001416.1 Reference assembly

      Range
      38360..38653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040630.1 CII-like transcriptional activator [Escherichia phage Lambda]

      See identical proteins and their annotated locations for NP_040630.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03042
      UniProtKB/TrEMBL
      A0A0K2FIH7, A2SY75
      Conserved Domains (1) summary
      pfam05269
      Location:4 → 82
      Phage_CII; Bacteriophage CII protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    1XWR_A.1
    1XWR_B.1
    1XWR_C.1
    1XWR_D.1
    1ZPQ_A.1
    1ZPQ_B.1
    1ZPQ_C.1
    1ZPQ_D.1

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