ced-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ced-5
Primary source: WormBase:WBGene00000419
Locus tag: CELE_C02F4.1
See related: AllianceGenome:WB:WBGene00000419
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables SH3 domain binding activity and enzyme binding activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and positive regulation of distal tip cell migration. Located in presynapse. Part of guanyl-nucleotide exchange factor complex. Is expressed in body wall muscle cell; hermaphrodite somatic gonadal cell; and intestinal cell. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and immunodeficiency 40. Orthologous to several human genes including DOCK1 (dedicator of cytokinesis 1); DOCK2 (dedicator of cytokinesis 2); and DOCK5 (dedicator of cytokinesis 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 19

Sequence:: Chromosome: IV; NC_003282.8 (10484110..10492913)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases.
Title: CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases.
CED-2 may regulate cell corpse engulfment by interacting with CED-5 through the N-terminal region rather than the PXXP motif.
Title: Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.
Epistatic analyses place mtm-1 upstream of the ternary GEF complex, which consists of ced-2, ced-5 and ced-12, and parallel to mig-2.
Title: The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.
findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis
Title: Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.
Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 plays a role in cell migration
Title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.
the PH domain of ELMO binds the Dock180-Rac complex in trans and stabilizes Rac in the nucleotide-free transition state
Title: PH domain of ELMO functions in trans to regulate Rac activation via Dock180.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F01D4.5 (e-PCR)
- UniSTS:316519

C02F4.1 (e-PCR)
- UniSTS:308891

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase regulator activity	TAS Traceable Author Statement more info	PubMed
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
contributes_to guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of distal tip cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle clustering	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of guanyl-nucleotide exchange factor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Dedicator of cytokinesis protein 1

NP_501938.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10484110..10492913

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069537.8 → NP_501938.1 Dedicator of cytokinesis protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501938.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EEN3

Conserved Domains (4) summary

cd08679
Location:415 → 608

C2_DOCK180_related; C2 domains found in Dedicator Of CytoKinesis 1 (DOCK 180) and related proteins

cd11684
Location:1225 → 1621

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

smart00326
Location:5 → 66

SH3; Src homology 3 domains

pfam16172
Location:82 → 394

DOCK_N; DOCK N-terminus