ANKRD35 ankyrin repeat domain 35 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANKRD35provided by HGNC
Official Full Name: ankyrin repeat domain 35provided by HGNC
Primary source: HGNC:HGNC:26323
See related: Ensembl:ENSG00000198483 AllianceGenome:HGNC:26323
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Biased expression in skin (RPKM 27.5), esophagus (RPKM 8.5) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (145866564..145885866, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (144983377..145002686, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (145549209..145568522)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits.
Title: Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	The interaction of HIV-1 CA with human cellular ankyrin repeat domain 35 protein (ANKRD35) is identified by yeast two-hybrid screen	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001280799.2 → NP_001267728.1 ankyrin repeat domain-containing protein 35 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.

Source sequence(s)

AC243547, AK294308, DA399526, HY327286

Consensus CDS

CCDS72868.1

UniProtKB/TrEMBL

B4DFX6, F6XZD3

Related

ENSP00000442671.2, ENST00000544626.2

Conserved Domains (4) summary

cd00204
Location:24 → 136

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:34 → 126

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:8 → 41

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:29 → 60

ANK; ANK repeat [structural motif]
NM_144698.5 → NP_653299.4 ankyrin repeat domain-containing protein 35 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC243547, AK294308, BC101618, DA399526, HY327286

Consensus CDS

CCDS72867.1

UniProtKB/Swiss-Prot

A6NEU0, B4DL62, Q3MJ10, Q8N283, Q96LS3

Related

ENSP00000347802.4, ENST00000355594.9

Conserved Domains (6) summary

COG1340
Location:676 → 968

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00204
Location:81 → 206

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam05278
Location:803 → 950

PEARLI-4; Arabidopsis phospholipase-like protein (PEARLI 4)

pfam12796
Location:58 → 150

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:24 → 74

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:53 → 84

ANK; ANK repeat [structural motif]