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    MTOR mechanistic target of rapamycin [ Gallus gallus (chicken) ]

    Gene ID: 419455, updated on 17-Aug-2024

    Summary

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    Symbol
    MTORprovided by CGNC
    Full Name
    mechanistic target of rapamycinprovided by CGNC
    Primary source
    CGNC:2430
    See related
    Ensembl:ENSGALG00010021746
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    FRAP1
    Orthologs
    human mouse all
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    Genomic context

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    See MTOR in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (4128908..4191557, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (4162049..4224128, complement)

    Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene spermidine synthase Neighboring gene exosome component 10 Neighboring gene angiopoietin like 7 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene pleckstrin homology and RUN domain containing M2 Neighboring gene solute carrier family 25 member 34 Neighboring gene transmembrane protein 82

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. mTor signaling is required for the formation of proliferating Müller glia-derived progenitor cells in the chick retina. Zelinka CP, et al. Development, 2016 Jun 1. PMID 27068108, Free PMC Article
    2. L-arginine upregulates the gene expression of target of rapamycin signaling pathway and stimulates protein synthesis in chicken intestinal epithelial cells. Yuan C, et al. Poult Sci, 2015 May. PMID 25771531
    3. Activation of mammalian target of rapamycin signaling in skeletal muscle of neonatal chicks: effects of dietary leucine and age. Deng H, et al. Poult Sci, 2014 Jan. PMID 24570430
    4. Effects of breed and dietary nutrient density on the growth performance, blood metabolite, and genes expression of target of rapamycin (TOR) signalling pathway of female broiler chickens. Wang XQ, et al. J Anim Physiol Anim Nutr (Berl), 2013 Aug. PMID 22731106
    5. Copper or/and arsenic induces autophagy by oxidative stress-related PI3K/AKT/mTOR pathways and cascaded mitochondrial fission in chicken skeletal muscle. Wang Y, et al. J Inorg Biochem, 2018 Nov. PMID 30096535

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miRNA-29-3p targets PTEN to regulate follicular development through the PI3K/Akt/mTOR signaling pathway.
      Title: miRNA-29-3p targets PTEN to regulate follicular development through the PI3K/Akt/mTOR signaling pathway.
    2. results showed that after Cu or/and As insult and accumulation, inhibited PI3K/AKT/mTOR pathway activated autophagy and disturbed mitochondrial dynamic, forming a positive feedback with redox disorder.
      Title: Copper or/and arsenic induces autophagy by oxidative stress-related PI3K/AKT/mTOR pathways and cascaded mitochondrial fission in chicken skeletal muscle.
    3. mTor signaling is required, but not sufficient, to stimulate Muller glia to give rise to proliferating progenitors.
      Title: mTor signaling is required for the formation of proliferating Müller glia-derived progenitor cells in the chick retina.
    4. The body weight gain and breast muscle yield of light chicks were improved by increasing dietary Methionine levels probably through alterations of MSTN transcription and phosphorylation of mTOR and FoxO4.
      Title: MSTN, mTOR and FoxO4 are involved in the enhancement of breast muscle growth by methionine in broilers with lower hatching weight.
    5. This study evaluated the effects of L-Arg on protein synthesis and genes expression involved in target of rapamycin (TOR) signaling pathway in chicken enterocytes.
      Title: L-arginine upregulates the gene expression of target of rapamycin signaling pathway and stimulates protein synthesis in chicken intestinal epithelial cells.
    6. High dietary leucine activates mTOR signaling pathways in skeletal muscle of neonatal chicks to stimulate muscle protein synthesis, and this pathway is attenuated with aging.
      Title: Activation of mammalian target of rapamycin signaling in skeletal muscle of neonatal chicks: effects of dietary leucine and age.
    7. These findings suggested that different genotypes respond differently to changes in dietary nutrient density and that lower-nutrient-density diets are optimal for the long-term housing of broiler chickens.
      Title: Effects of breed and dietary nutrient density on the growth performance, blood metabolite, and genes expression of target of rapamycin (TOR) signalling pathway of female broiler chickens.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase mTOR
    Names
    FK506 binding protein 12-rapamycin associated protein 1
    mechanistic target of rapamycin (serine/threonine kinase)
    XP_040545102.1
    XP_417614.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4128908..4191557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_417614.8 → XP_417614.3  serine/threonine-protein kinase mTOR

      UniProtKB/TrEMBL
      F1NUX4
      Related
      ENSGALP00010031768.1, ENSGALT00010052862.1
      Conserved Domains (2) summary
      COG5032
      Location:349 → 2521
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      sd00044
      Location:641 → 667
      HEAT; HEAT repeat [structural motif]

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4162049..4224128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040689168.2 → XP_040545102.1  serine/threonine-protein kinase mTOR

      UniProtKB/TrEMBL
      F1NUX4
      Conserved Domains (2) summary
      COG5032
      Location:349 → 2521
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      sd00044
      Location:641 → 667
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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