EMP1 epithelial membrane protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EMP1provided by HGNC
Official Full Name: epithelial membrane protein 1provided by HGNC
Primary source: HGNC:HGNC:3333
See related: Ensembl:ENSG00000134531 MIM:602333; AllianceGenome:HGNC:3333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TMP; CL-20; EMP-1
Summary: Involved in apoptotic process and bleb assembly. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in esophagus (RPKM 1426.7), gall bladder (RPKM 194.7) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (13196726..13219941)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (13071022..13094235)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (13349660..13372875)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EMP1 correlated with cancer progression and immune characteristics in pan-cancer and ovarian cancer.
Title: EMP1 correlated with cancer progression and immune characteristics in pan-cancer and ovarian cancer.
Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
Title: Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by using integrated bioinformatics analysis.
Title: Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by using integrated bioinformatics analysis.
Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of PPAR gamma signaling.
Title: Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of PPAR gamma signaling.
Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer.
Title: Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer.
Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer.
Title: Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer.
Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma.
Title: Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma.
EMP1 promotes the malignant progression of osteosarcoma through the IRX2/MMP9 axis.
Title: EMP1 promotes the malignant progression of osteosarcoma through the IRX2/MMP9 axis.
Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
Title: Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
Epithelial Membrane Protein 2 Suppresses Non-Small Cell Lung Cancer Cell Growth by Inhibition of MAPK Pathway.
Title: Epithelial Membrane Protein 2 Suppresses Non-Small Cell Lung Cancer Cell Growth by Inhibition of MAPK Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of coronary artery calcification among African Americans, a meta-analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78445 (e-PCR)
- UniSTS:15177

SHGC-150875 (e-PCR)
- UniSTS:173643

G42649 (e-PCR)
- UniSTS:94549

RH77807 (e-PCR)
- UniSTS:4965

RH69862 (e-PCR)
- UniSTS:24180

SHGC-81206 (e-PCR)
- UniSTS:102028

D12S1580 (e-PCR), detects polymorphism
- UniSTS:39335

D12S1239E (e-PCR)
- UniSTS:151486

G62401 (e-PCR)
- UniSTS:139261

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in bleb assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermis development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: epithelial membrane protein 1

Names: tumor-associated membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.