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    Susd4 sushi domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 96935, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Susd4provided by MGI
    Official Full Name
    sushi domain containing 4provided by MGI
    Primary source
    MGI:MGI:2138351
    See related
    Ensembl:ENSMUSG00000038576 AllianceGenome:MGI:2138351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E430021N18Rik
    Summary
    Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. Is expressed in brain and cortical plate. Orthologous to human SUSD4 (sushi domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 29.8), cortex adult (RPKM 26.8) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Susd4 in Genome Data Viewer
    Location:
    1 H5; 1 85.94 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (182591609..182724161)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (182764044..182896596)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene calpain 8 Neighboring gene coiled-coil domain containing 185 Neighboring gene STARR-seq mESC enhancer starr_03290 Neighboring gene STARR-seq mESC enhancer starr_03291 Neighboring gene STARR-seq mESC enhancer starr_03292 Neighboring gene STARR-seq mESC enhancer starr_03293 Neighboring gene STARR-seq mESC enhancer starr_03294 Neighboring gene toll-like receptor 5 Neighboring gene predicted gene, 33747

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sushi domain-containing protein 4 controls synaptic plasticity and motor learning. González-Calvo I, et al. Elife, 2021 Mar 4. PMID 33661101, Free PMC Article
    2. Tissue distribution and functional analysis of Sushi domain-containing protein 4. Tu Z, et al. Am J Pathol, 2010 May. PMID 20348246, Free PMC Article
    3. The Complement Regulator Susd4 Influences Nervous-System Function and Neuronal Morphology in Mice. Zhu H, et al. iScience, 2020 Mar 27. PMID 32179479, Free PMC Article
    4. Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant. Hai Q, et al. Arterioscler Thromb Vasc Biol, 2018 Jan. PMID 29097366, Free PMC Article
    5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sushi domain-containing protein 4 controls synaptic plasticity and motor learning.
      Title: Sushi domain-containing protein 4 controls synaptic plasticity and motor learning.
    2. analysis of cloning, expression, refolding, and tissue distribution of Sushi domain-containing protein 4
      Title: Tissue distribution and functional analysis of Sushi domain-containing protein 4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30368

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of complement activation, alternative pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of complement activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sushi domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356461.1 → NP_001343390.1  sushi domain-containing protein 4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Consensus CDS
      CCDS15590.1
      UniProtKB/Swiss-Prot
      Q8BH32, Q8VC43
      Related
      ENSMUSP00000119488.2, ENSMUST00000153348.8
      Conserved Domains (2) summary
      smart00032
      Location:243 → 297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57 → 238
      PHA02927; secreted complement-binding protein; Provisional

    2. NM_001356462.1 → NP_001343391.1  sushi domain-containing protein 4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Consensus CDS
      CCDS15590.1
      UniProtKB/Swiss-Prot
      Q8BH32, Q8VC43
      Conserved Domains (2) summary
      smart00032
      Location:243 → 297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57 → 238
      PHA02927; secreted complement-binding protein; Provisional

    3. NM_001356463.1 → NP_001343392.1  sushi domain-containing protein 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Conserved Domains (2) summary
      smart00032
      Location:245 → 299
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57 → 238
      PHA02927; secreted complement-binding protein; Provisional

    4. NM_001356464.1 → NP_001343393.1  sushi domain-containing protein 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Conserved Domains (2) summary
      smart00032
      Location:245 → 299
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57 → 238
      PHA02927; secreted complement-binding protein; Provisional

    5. NM_144796.5 → NP_659045.2  sushi domain-containing protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_659045.2

      Status: VALIDATED

      Source sequence(s)
      AC151579, AC170917
      Consensus CDS
      CCDS15590.1
      UniProtKB/Swiss-Prot
      Q8BH32, Q8VC43
      Related
      ENSMUSP00000082873.4, ENSMUST00000085724.5
      Conserved Domains (2) summary
      smart00032
      Location:243 → 297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57 → 238
      PHA02927; secreted complement-binding protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      182591609..182724161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243824.2 → XP_030099684.1  sushi domain-containing protein 4 isoform X3

      Conserved Domains (2) summary
      cd00033
      Location:81 → 138
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:35 → 197
      PHA02927; secreted complement-binding protein; Provisional

    2. XM_030243823.1 → XP_030099683.1  sushi domain-containing protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q8BH32, Q8VC43
      Conserved Domains (2) summary
      smart00032
      Location:243 → 297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57 → 238
      PHA02927; secreted complement-binding protein; Provisional

    3. XM_006497063.2 → XP_006497126.1  sushi domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006497126.1

      UniProtKB/Swiss-Prot
      Q8BH32
      Conserved Domains (2) summary
      smart00032
      Location:245 → 299
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:57 → 238
      PHA02927; secreted complement-binding protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH32.1 GenPept UniProtKB/Swiss-Prot:Q8BH32

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