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    HA haemagglutinin [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

    Gene ID: 956529, updated on 6-Oct-2023

    Summary

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    Gene symbol
    HA
    Gene description
    haemagglutinin
    Locus tag
    FLUAVs4gp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serotype: H1N1)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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    Genomic context

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    Location:
    segment: 4
    Sequence:
    NC_002017.1 (33..1733)

    NC_002017.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002017.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis and sequence co-evolution analysis of the hemagglutinin protein of pandemic influenza A/H1N1 (2009) virus. Tse H, et al. Exp Biol Med (Maywood), 2011 Aug. PMID 21727184
    2. Genetic diversity of HA1 domain of heammaglutinin gene of influenza A(H1N1)pdm09 in Tunisia. El Moussi A, et al. Virol J, 2013 May 16. PMID 23679923, Free PMC Article
    3. Genetic requirement for hemagglutinin glycosylation and its implications for influenza A H1N1 virus evolution. Kim JI, et al. J Virol, 2013 Jul. PMID 23637398, Free PMC Article
    4. Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene. Mo JS, et al. J Virol, 2022 Nov 23. PMID 36317880, Free PMC Article
    5. 1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice. Watanabe T, et al. J Virol, 2013 May. PMID 23449804, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene.
      Title: Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene.
    2. Monoclonal Antibody Targeting the HA191/199 Region of H1N1 Influenza Virus Mediates the Damage of Neural Cells.
      Title: Monoclonal Antibody Targeting the HA191/199 Region of H1N1 Influenza Virus Mediates the Damage of Neural Cells.
    3. Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018-2019.
      Title: Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018-2019.
    4. Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope.
      Title: Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope.
    5. Influenza Hemagglutinin Head Domain Mimicry by Rational Design.
      Title: Influenza Hemagglutinin Head Domain Mimicry by Rational Design.
    6. N-Linked Glycans and K147 Residue on Hemagglutinin Synergize To Elicit Broadly Reactive H1N1 Influenza Virus Antibodies.
      Title: N-Linked Glycans and K147 Residue on Hemagglutinin Synergize To Elicit Broadly Reactive H1N1 Influenza Virus Antibodies.
    7. Monoclonal antibody PR8-25 (MAb PR8-25) shown neutralizing activity both in vitro and in vivo. MAb PR8-25 shown reactivity with H1 subtype of influenza virus. The epitope of MAb PR8-25, 328-339aa, targeted in the stem region of hemagglutinin of H1N1 influenza A virus and located at the C-terminal of the HA1 fragment.
      Title: An epitope on the stem region of hemagglutinin of H1N1 influenza A virus recognized by neutralizing monoclonal antibody.
    8. Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation.
      Title: Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation.
    9. cellular kinase, casein kinase 1alpha (CK1alpha), is crucial for IAV HA-induced degradation of both IFNGR1 and IFNAR1.
      Title: Casein Kinase 1α Mediates the Degradation of Receptors for Type I and Type II Interferons Caused by Hemagglutinin of Influenza A Virus.
    10. MAb, MA-H generated against the seasonal A/Solomon Islands/03/2006 (H1N1) rHA binds within the head domain and bound the seasonal H1N1 (A/Solomon Islands/03/2006 and A/New Caledonia/20/1990) rHAs with high affinity (KD; 0.72-8.23 nM). MA-H showed high HI (2.50 mug/mL) and in vitro neutralization (IC50 = 2.61 mug/mL) activity against the A/Solomon Islands/03/2006 virus
      Title: Neutralization and Binding Profile of Monoclonal Antibodies Generated Against Influenza A H1N1 Viruses.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    haemagglutinin
    Names
    HA1
    HA2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002017.1 Reference assembly

      Range
      33..1733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040980.1 haemagglutinin [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

      See identical proteins and their annotated locations for NP_040980.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2R4QPL5, R9WNJ1, S5FR35
      Conserved Domains (1) summary
      pfam00509
      Location:20 → 566
      Hemagglutinin; Haemagglutinin

    2. YP_163735.1 HA1

      UniProtKB/TrEMBL
      Q67131
      Conserved Domains (1) summary
      pfam00509
      Location:3 → 327
      Hemagglutinin; Haemagglutinin

    3. YP_163736.1 HA2

      Conserved Domains (1) summary
      pfam00509
      Location:1 → 222
      Hemagglutinin; Haemagglutinin
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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