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    Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94173, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Idh3bprovided by RGD
    Official Full Name
    isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit betaprovided by RGD
    Primary source
    RGD:621881
    See related
    EnsemblRapid:ENSRNOG00000007316 AllianceGenome:RGD:621881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme activator activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to human IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 1719.4), Muscle (RPKM 1296.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Idh3b in Genome Data Viewer
    Location:
    3q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (137934971..137940275, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117481845..117486909, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122808564..122813638, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NOP56 ribonucleoprotein Neighboring gene small nucleolar RNA SNORD56 Neighboring gene small nucleolar RNA, C/D box 57 Neighboring gene ribosomal protein L31-like 6 Neighboring gene ribosomal protein S12-like 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of NAD(+)-dependent isocitrate dehydrogenase in brown adipose tissue. Shinohara Y, et al. Biochem Biophys Res Commun, 2001 Mar 2. PMID 11237704
    2. Preparation and properties of mitochondria derived from synaptosomes. Lai JC, et al. Biochem J, 1976 Feb 15. PMID 938457, Free PMC Article
    3. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, et al. J Biol Chem, 2003 Dec 26. PMID 14555658
    4. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
    5. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94111

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isocitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of isocitrate dehydrogenase complex (NAD+) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of isocitrate dehydrogenase complex (NAD+) ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
    Names
    NAD(+)-specific ICDH subunit beta
    NAD+-specific isocitrate dehydrogenase b subunit
    isocitrate dehydrogenase (NAD(+)) 3 beta
    isocitrate dehydrogenase 3 (NAD+) beta
    isocitric dehydrogenase subunit beta
    NP_446033.1
    XP_006235110.1
    XP_063140819.1
    XP_063140820.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429519.1 → NP_001416448.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_053581.2 → NP_446033.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_446033.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q68FX0
      UniProtKB/TrEMBL
      A6HQ80
      Related
      ENSRNOP00000103294.1, ENSRNOT00000146469.1
      Conserved Domains (1) summary
      cl00445
      Location:47 → 380
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      137934971..137940275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235048.5 → XP_006235110.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00445
      Location:47 → 377
      Iso_dh; Isocitrate/isopropylmalate dehydrogenase

    2. XM_063284749.1 → XP_063140819.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMM2
      Related
      ENSRNOP00000093884.1, ENSRNOT00000112690.2

    3. XM_063284750.1 → XP_063140820.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FX0.1 GenPept UniProtKB/Swiss-Prot:Q68FX0

    Gene LinkOut

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