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    ZNF799 zinc finger protein 799 [ Homo sapiens (human) ]

    Gene ID: 90576, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF799provided by HGNC
    Official Full Name
    zinc finger protein 799provided by HGNC
    Primary source
    HGNC:HGNC:28071
    See related
    Ensembl:ENSG00000196466 MIM:619916; AllianceGenome:HGNC:28071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIT40; HIT-40; ZNF842
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 2.5), endometrium (RPKM 2.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF799 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12390016..12415084, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12518440..12543482, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12500830..12512085, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12444503-12445368 Neighboring gene zinc finger protein 442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14052 Neighboring gene ribosomal protein S29 pseudogene 23 Neighboring gene NANOG hESC enhancer GRCh37_chr19:12501177-12501678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14055 Neighboring gene zinc finger protein 443 Neighboring gene zinc finger protein 709

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC71805

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 799
    Names
    zinc finger protein 14
    zinc finger protein 842
    zinc finger protein HIT-40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080821.3 → NP_001074290.1  zinc finger protein 799 isoform 1

      See identical proteins and their annotated locations for NP_001074290.1

      Status: VALIDATED

      Source sequence(s)
      AC008758
      Consensus CDS
      CCDS45989.1
      UniProtKB/Swiss-Prot
      Q96GE5
      Related
      ENSP00000411084.2, ENST00000430385.3
      Conserved Domains (5) summary
      smart00349
      Location:4 → 44
      KRAB; krueppel associated box
      COG5048
      Location:223 → 640
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:478 → 498
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:518 → 542
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001322497.2 → NP_001309426.1  zinc finger protein 799 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA995448, AK027660, AL556986, HY132063
      Consensus CDS
      CCDS82297.1
      UniProtKB/TrEMBL
      D3YTF2
      Related
      ENSP00000415278.1, ENST00000419318.5
      Conserved Domains (3) summary
      COG5048
      Location:116 → 519
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:486 → 510
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001322498.2 → NP_001309427.1  zinc finger protein 799 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA995448, AC008758, AK027660, DA768219, DA910536
      Consensus CDS
      CCDS82297.1
      UniProtKB/TrEMBL
      D3YTF2
      Conserved Domains (3) summary
      COG5048
      Location:116 → 519
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:486 → 510
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12390016..12415084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439649.1 → XP_047295605.1  zinc finger protein 799 isoform X1

      UniProtKB/Swiss-Prot
      Q96GE5

    2. XM_047439650.1 → XP_047295606.1  zinc finger protein 799 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12518440..12543482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322555.1 → XP_054178530.1  zinc finger protein 799 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_203381.1: Suppressed sequence

      Description
      NM_203381.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96GE5.4 GenPept UniProtKB/Swiss-Prot:Q96GE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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