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    F2RL3 F2R like thrombin or trypsin receptor 3 [ Homo sapiens (human) ]

    Gene ID: 9002, updated on 28-Oct-2024

    Summary

    Official Symbol
    F2RL3provided by HGNC
    Official Full Name
    F2R like thrombin or trypsin receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:3540
    See related
    Ensembl:ENSG00000127533 MIM:602779; AllianceGenome:HGNC:3540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAR4
    Summary
    This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]
    Expression
    Broad expression in fat (RPKM 1.9), stomach (RPKM 1.3) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See F2RL3 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (16888999..16892606)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17023836..17027443)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16999810..17003417)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NACHT and WD repeat domain containing 1 Neighboring gene uncharacterized LOC124904648 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:16928291-16928487 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:16936141-16936818 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16939935-16940436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14248 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16947461-16947962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16957115-16957616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16957617-16958116 Neighboring gene SIN3 transcription regulator family member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16996894-16997394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17000485-17001084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10318 Neighboring gene C3 and PZP like alpha-2-macroglobulin domain containing 8 Neighboring gene RNA, 7SL, cytoplasmic 835, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 823, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thrombin-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    proteinase-activated receptor 4
    Names
    F2R like thrombin/trypsin receptor 3
    PAR-4
    coagulation factor II (thrombin) receptor-like 3
    protease-activated receptor-4
    thrombin receptor-like 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032894.1 RefSeqGene

      Range
      4985..8592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_633

    mRNA and Protein(s)

    1. NM_003950.4NP_003941.2  proteinase-activated receptor 4 preproprotein

      See identical proteins and their annotated locations for NP_003941.2

      Status: REVIEWED

      Source sequence(s)
      AC008737, AF055917, BP281855, BQ269855
      Consensus CDS
      CCDS12350.1
      UniProtKB/Swiss-Prot
      O76067, Q6DK42, Q96RI0
      Related
      ENSP00000248076.2, ENST00000248076.4
      Conserved Domains (1) summary
      pfam00001
      Location:131340
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      16888999..16892606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      17023836..17027443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)