Slc5a7 solute carrier family 5 member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc5a7provided by RGD
Official Full Name: solute carrier family 5 member 7provided by RGD
Primary source: RGD:69270
See related: EnsemblRapid:ENSRNOG00000010597 AllianceGenome:RGD:69270
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cht1; rCHT1
Summary: Enables choline transmembrane transporter activity. Involved in acetylcholine biosynthetic process and choline transport. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and plasma membrane raft. Biomarker of asthma. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 7; congenital myasthenic syndrome 20; and depressive disorder. Orthologous to human SLC5A7 (solute carrier family 5 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 22.4), Heart (RPKM 3.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (7922693..7953509, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (7595440..7626258, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (5294377..5330822, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of the High-Affinity Choline Transporter 1 in the Spinal Cord Relieves Stress-Induced Hyperalgesia.
Title: Activation of the High-Affinity Choline Transporter 1 in the Spinal Cord Relieves Stress-Induced Hyperalgesia.
Four genes were significantly downregulated in the PFC [prefrontal cortex ]of SHR[spontaneously hypertensive rat ] compared to Wistar rats (Gad2, Chrnb4, Slc5a7, and Qrfpr) and none in nucleus accumbens.
Title: Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: relevance to neuropsychiatric disorders.
Young and old cardiac myocytes are able to synthesize, transport and excrete acetylcholine in the heart. Adult cardiomyocytes express the high affinity choline transporter 1 (CHT-1).
Title: Acetylcholine as an age-dependent non-neuronal source in the heart.
ultrastructural distribution of CHT in anteroventral thalamus and ventral tegmental area; immunoreactivity for this protein was predominantly localized to synaptic vesicles and minimally to the plasma membrane of axons in both regions
Title: Ultrastructural localization of high-affinity choline transporter in the rat anteroventral thalamus and ventral tegmental area: differences in axon morphology and transporter distribution.
CHT1 plays a key role in acetylcholine synthesis in NIH3T3ChAT 112-1 cells which stably expresses both rat CHT1 and mouse ChAT.
Title: Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase.
findings show here that internalized CHT1 is rapidly recycled back to the cell surface
Title: Regulated recycling and plasma membrane recruitment of the high-affinity choline transporter.
18.0 mg/kg dose of chlorpyrifos was associated with (brain region-dependent) decreases in nerve growth factor receptors and cholinergic proteins including the high-affinity choline transporter
Title: Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing.
high-affinity choline transporter, choline transporter 1, in nerve fibers and epithelial cells in the human and rat skin supporting the pivotal role of this transporter in both the neuronal and non-neuronal cholinergic system of the skin.
Title: Expression of the high-affinity choline transporter, CHT1, in the neuronal and non-neuronal cholinergic system of human and rat skin.
This protein is expressed in the rat trachea.
Title: Expression of the high-affinity choline transporter, CHT1, in the rat trachea.
close apposition of CHT1 to reported sites of localization of choline acetyltransferase in these cells is strongly in favour of ACh synthesis being fuelled by choline uptake via CHT1 in these epithelia
Title: Expression of the high-affinity choline transporter CHT1 in epithelia.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables choline binding	IEA Inferred from Electronic Annotation more info
enables choline binding	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables choline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables choline transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables choline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables choline:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables choline:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables choline:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acetylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in acetylcholine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within acetylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in choline transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in choline transport	IDA Inferred from Direct Assay more info	PubMed
involved_in choline transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within choline transport	ISO Inferred from Sequence Orthology more info
involved_in choline transport	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuromuscular synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, cholinergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, cholinergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, cholinergic	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in perikaryon	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: high affinity choline transporter 1

Names: CHT; hemicholinium-3-sensitive choline transporter; solute carrier family 5 (choline transporter), member 7; solute carrier family 5 (sodium/choline cotransporter), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053521.2 → NP_445973.2 high affinity choline transporter 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q9JMD7

UniProtKB/TrEMBL

A6KQA3, G3V7G1

Related

ENSRNOP00000014548.4, ENSRNOT00000014548.7

Conserved Domains (1) summary

cd11474
Location:8 → 495

SLC5sbd_CHT; Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain