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Dll1 delta like canonical Notch ligand 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84010, updated on 2-Nov-2024

Summary

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Official Symbol: Dll1provided by RGD
Official Full Name: delta like canonical Notch ligand 1provided by RGD
Primary source: RGD:70949
See related: EnsemblRapid:ENSRNOG00000059984 AllianceGenome:RGD:70949
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables Notch binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Notch signaling pathway. Predicted to be located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Predicted to be active in plasma membrane. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 99.8), Lung (RPKM 56.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Dll1 in Genome Data Viewer

Location:: 1q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (64985161..64993274, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (56312062..56320177, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (57318621..57326732, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Localization of DLL1- and NICD-positive osteoblasts in cortical bone during postnatal growth in rats.
Title: Localization of DLL1- and NICD-positive osteoblasts in cortical bone during postnatal growth in rats.
these results showed that Dll1 enhanced RBL-2H3 cell degranulation and cytokine production via a novel Notch/downstream of tyrosine kinases 1 (Dok-1)/MAPKs pathway, suggesting Notch signaling was a key mediator in the effect phase of food allergy
Title: Notch ligand Delta-like1 enhances degranulation and cytokine production through a novel Notch/Dok-1/MAPKs pathway in vitro.
The immunolocalisation of the stem cell-specific markers Notch-1, Delta, CD105 and CD166 was studied in rat femoral head articular cartilage. Corticosteroid (methylprednisolone) treatment was found to decrease the activity of these markers.
Title: The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage.
Notch1 ligand Delta-1 mRNA expression in postnatal rat microglia of corpus callosum and subventricular zone is reduced, while that of Notch1 is enhanced.
Title: Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells.
Delta-1/Notch-2/Hes-1 signaling pathway may regulate the regeneration and proliferation of renal tubules during acute kidney injury.
Title: Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dll1 (e-PCR), detects polymorphism
- UniSTS:142854

Dll1 (e-PCR), detects polymorphism
- UniSTS:259601

UniSTS:465448 (e-PCR)
- UniSTS:465448

Dll1 (e-PCR), detects polymorphism
- UniSTS:465448

Dll1 (e-PCR), detects polymorphism
- UniSTS:545925

Dll1 (e-PCR), detects polymorphism
- UniSTS:526072

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables Notch binding	TAS Traceable Author Statement more info	PubMed
enables Tat protein binding	IEA Inferred from Electronic Annotation more info
enables Tat protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Notch signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in Notch signaling pathway involved in arterial endothelial cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway involved in arterial endothelial cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway involved in arterial endothelial cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in astrocyte development	IEA Inferred from Electronic Annotation more info
involved_in astrocyte development	ISO Inferred from Sequence Orthology more info
involved_in astrocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in auditory receptor cell fate commitment	NAS Non-traceable Author Statement more info	PubMed
involved_in cell fate determination	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cerebellar Purkinje cell layer structural organization	IEA Inferred from Electronic Annotation more info
involved_in cerebellar Purkinje cell layer structural organization	ISO Inferred from Sequence Orthology more info
involved_in cerebellar Purkinje cell layer structural organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellar molecular layer formation	IEA Inferred from Electronic Annotation more info
involved_in cerebellar molecular layer formation	ISO Inferred from Sequence Orthology more info
involved_in cerebellar molecular layer formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in clathrin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in compartment pattern specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within compartment pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in developmental process	IEA Inferred from Electronic Annotation more info
involved_in endothelial tip cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in endothelial tip cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in endothelial tip cell fate specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart looping	IEA Inferred from Electronic Annotation more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in inhibition of neuroepithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inner ear auditory receptor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in lateral inhibition	IEA Inferred from Electronic Annotation more info
involved_in lateral inhibition	ISO Inferred from Sequence Orthology more info
involved_in lateral inhibition	ISS Inferred from Sequence or Structural Similarity more info
involved_in left/right axis specification	IEA Inferred from Electronic Annotation more info
involved_in left/right axis specification	ISO Inferred from Sequence Orthology more info
involved_in loop of Henle development	IEA Inferred from Electronic Annotation more info
involved_in loop of Henle development	ISO Inferred from Sequence Orthology more info
involved_in marginal zone B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in marginal zone B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in marginal zone B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inner ear auditory receptor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nephron development	ISO Inferred from Sequence Orthology more info
involved_in nephron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in neuroepithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuroepithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron fate specification	IEA Inferred from Electronic Annotation more info
involved_in neuron fate specification	ISO Inferred from Sequence Orthology more info
involved_in neuron fate specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in neuronal stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in organ growth	IEA Inferred from Electronic Annotation more info
involved_in organ growth	ISO Inferred from Sequence Orthology more info
involved_in organ growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle tissue growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in proximal tubule development	IEA Inferred from Electronic Annotation more info
involved_in proximal tubule development	ISO Inferred from Sequence Orthology more info
involved_in proximal/distal pattern formation	IEA Inferred from Electronic Annotation more info
involved_in proximal/distal pattern formation	ISO Inferred from Sequence Orthology more info
involved_in proximal/distal pattern formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of skeletal muscle tissue growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle tissue growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of somitogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of somitogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial growth factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retina development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
involved_in retina morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retina morphogenesis in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle tissue growth	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle tissue growth	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin epidermis development	IEA Inferred from Electronic Annotation more info
involved_in skin epidermis development	ISO Inferred from Sequence Orthology more info
involved_in skin epidermis development	ISS Inferred from Sequence or Structural Similarity more info
involved_in somite specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somite specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in spinal cord development	IEA Inferred from Electronic Annotation more info
involved_in spinal cord development	ISO Inferred from Sequence Orthology more info
involved_in spinal cord development	ISS Inferred from Sequence or Structural Similarity more info
involved_in type B pancreatic cell development	IEA Inferred from Electronic Annotation more info
involved_in type B pancreatic cell development	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: delta-like protein 1

Names: delta1; drosophila Delta homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032063.3 → NP_114452.2 delta-like protein 1 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P97677

UniProtKB/TrEMBL

A6KB40, G3V7W6

Related

ENSRNOP00000073159.1, ENSRNOT00000080429.3

Conserved Domains (4) summary

smart00051
Location:158 → 220

DSL; delta serrate ligand

cd00054
Location:442 → 477

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:484 → 514

EGF; EGF-like domain

pfam07657
Location:22 → 91

MNNL; N-terminus of Notch ligand