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    C3ar1 complement C3a receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84007, updated on 14-Nov-2024

    Summary

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    Official Symbol
    C3ar1provided by RGD
    Official Full Name
    complement C3a receptor 1provided by RGD
    Primary source
    RGD:620537
    See related
    EnsemblRapid:ENSRNOG00000009211 AllianceGenome:RGD:620537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables complement component C3a binding activity and complement component C3a receptor activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of cell population proliferation; and tolerance induction to nonself antigen. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study adult respiratory distress syndrome. Biomarker of asthma and lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 15.4), Kidney (RPKM 15.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C3ar1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (157747419..157756609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (156074747..156084680, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (155681767..155691240, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 3 Neighboring gene forkhead box J2 Neighboring gene ribosomal protein L31, pseudogene 10 Neighboring gene NECAP endocytosis associated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C3aR in astrocytes mediates post-thoracotomy pain by inducing A1 astrocytes in male rats. Zhu A, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jun. PMID 36871753
    2. Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation. Fukuoka Y, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464274
    3. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Sohn JH, et al. Nat Med, 2003 Feb. PMID 12514742, Free PMC Article
    4. Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats. Ikeda K, et al. Clin Exp Hypertens, 2014. PMID 23713944
    5. Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. Proctor LM, et al. Br J Pharmacol, 2004 Jun. PMID 15159277, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C3aR in astrocytes mediates post-thoracotomy pain by inducing A1 astrocytes in male rats.
      Title: C3aR in astrocytes mediates post-thoracotomy pain by inducing A1 astrocytes in male rats.
    2. Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis Affected the Prognosis of UC by Modulating the Pyroptosis and Expression of Caspase-11.
      Title: Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis Affected the Prognosis of UC by Modulating the Pyroptosis and Expression of Caspase-11.
    3. C3aRA ameliorated T2DN by inhibiting IKBalpha phosphorylation and cytokine release, and also TGF-beta/Smad3 signaling and ECM deposition
      Title: C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway.
    4. C5aR and C5L2, but not C3aR, are expressed on CD11b-positive leukocytes in islet preparations
      Title: Expression of receptors for anaphylatoxins C3a and C5a on rat islet preparations.
    5. The C3 and C3a receptor system may primarily be involved in the pathogenesis of renal remodeling in hypertensive rats.
      Title: Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats.
    6. The binding of TLQP-21 to C3AR1 not only has effects on signaling but also modulates cellular functions
      Title: Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.
    7. Role of C3ar1 in the development of the rat cerebellum is reported.
      Title: Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum.
    8. results provide the first evidence that C3aR and C5aR are both expressed in cerebellar granule cells during development and that C5a, but not C3a, is a potent inhibitor of apoptotic cell death in cultured granule neurons
      Title: Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables complement component C3a binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables complement component C3a receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables complement component C3a receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables complement component C3a receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables complement component C3a receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables complement component C3a receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables complement component C5a receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement component C5a signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in complement receptor mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement receptor mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of glomerular mesangial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vascular endothelial growth factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tolerance induction to nonself antigen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C3a anaphylatoxin chemotactic receptor
    Names
    C3AR
    C3a-R
    complement component 3a receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032060.2 → NP_114449.2  C3a anaphylatoxin chemotactic receptor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      O55197
      UniProtKB/TrEMBL
      A6ILG1, G3V759
      Related
      ENSRNOP00000012216.2, ENSRNOT00000012216.5
      Conserved Domains (2) summary
      cd14964
      Location:25 → 51
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:24 → 434
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      157747419..157756609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237314.5 → XP_006237376.1  C3a anaphylatoxin chemotactic receptor isoform X1

      See identical proteins and their annotated locations for XP_006237376.1

      UniProtKB/Swiss-Prot
      O55197
      UniProtKB/TrEMBL
      A6ILG1, G3V759
      Related
      ENSRNOP00000094051.1, ENSRNOT00000106930.2
      Conserved Domains (2) summary
      cd14964
      Location:25 → 51
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:24 → 434
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55197.1 GenPept UniProtKB/Swiss-Prot:O55197

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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