Rxrg retinoid X receptor gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rxrgprovided by RGD
Full Name: retinoid X receptor gammaprovided by RGD
Primary source: RGD:620046
See related: EnsemblRapid:ENSRNOG00000004537 AllianceGenome:RGD:620046
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable molecular condensate scaffold activity; nuclear receptor activity; and retinoic acid-responsive element binding activity. Involved in several processes, including nervous system development; regulation of myelination; and response to retinoic acid. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 248.0), Muscle (RPKM 230.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (82276330..82318097)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (79743430..79785173)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (85818473..85868555)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the results of the present study revealed that miR3305p acts as a critical regulator of RXRgamma, and is able to determinate the fate of MSCs to differentiate into adipocytes. This suggests that miR3305p and RXRgamma may be target molecules for controlling metabolic diseases.
Title: miR‑330‑5p inhibits H2O2‑induced adipogenic differentiation of MSCs by regulating RXRγ.
RXRgamma was absent in the female rat brain, while it was observed in some regions in the male.
Title: Expression of retinoic acid receptors and retinoid X receptors in normal and vitamin A deficient adult rat brain.
These results suggest that HIF-1 may be involved in hypoxia-induced suppression of fatty acid metabolism in cardiomyocytes by reducing the DNA binding activity of PPARalpha/RXR.
Title: Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor.
Ectopic expression of PPARgamma/RXRalpha increases fatty acid uptake and deposition as triacylglycerides.
Title: Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Rxrg (e-PCR), detects polymorphism
- UniSTS:546588

Rxrg (e-PCR), detects polymorphism
- UniSTS:507203

RH135186 (e-PCR)
- UniSTS:218463

RH129058 (e-PCR)
- UniSTS:212366

Rxrg (e-PCR), detects polymorphism
- UniSTS:536548

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular condensate scaffold activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables retinoic acid-responsive element binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in peripheral nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of myelination	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoic acid receptor RXR-gamma

Names: RXR gamma-1; nuclear receptor subfamily 2 group B member 3; retinoic X receptor gamma-1; retinoic acid receptor RXR-gamma-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031765.1 → NP_113953.1 retinoic acid receptor RXR-gamma

See identical proteins and their annotated locations for NP_113953.1

Status: PROVISIONAL

Source sequence(s)

BC091363

UniProtKB/Swiss-Prot

Q5BJR8

UniProtKB/TrEMBL

A0A0G2JZ22, A6IDL7

Related

ENSRNOP00000105016.1, ENSRNOT00000121542.1

Conserved Domains (3) summary

cd06943
Location:233 → 441

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:137 → 213

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

pfam11825
Location:25 → 133

Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

82276330..82318097

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091122.2 → XP_038947050.1 retinoic acid receptor RXR-gamma isoform X1

UniProtKB/TrEMBL

A0A0G2JZ22, A0A8L2Q373

Related

ENSRNOP00000006117.5, ENSRNOT00000006117.7

Conserved Domains (3) summary

cd06943
Location:233 → 442

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:137 → 213

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

pfam11825
Location:25 → 133

Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
XM_039091123.2 → XP_038947051.1 retinoic acid receptor RXR-gamma isoform X2

UniProtKB/TrEMBL

Q64116

Conserved Domains (2) summary

cd06943
Location:110 → 319

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:14 → 90

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers