Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rradprovided by RGD
Official Full Name: RRAD, Ras related glycolysis inhibitor and calcium channel regulatorprovided by RGD
Primary source: RGD:69357
See related: EnsemblRapid:ENSRNOG00000011901 AllianceGenome:RGD:69357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity and calcium channel regulator activity. Involved in negative regulation of cell growth. Predicted to be located in T-tubule. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 894.3), Muscle (RPKM 95.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 19p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (360581..363874)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (354184..357424)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (561696..564929)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression increased significantly in the nonunions, compared to that in the standard healing fractures, at post-fracture days 14, 21, and 28
Title: Ras associated with diabetes may play a role in fracture nonunion development in rats.
Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs
Title: Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.
Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor in failing hearts.
Title: Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor.
Rad-triggered apoptosis was mediated by the activation of p38 MAPK.
Title: Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase.
Results establish Rad as a novel endogenous regulator of cardiac EC coupling and betaAR signaling and support a parsimonious model in which Rad buffers Ca(v)beta to modulate LCC activity, EC coupling, and betaAR responsiveness.
Title: Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.
Rad is a novel mediator that inhibits cardiac hypertrophy through the CaMKII pathway
Title: Rad GTPase deficiency leads to cardiac hypertrophy.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of high voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GTP-binding protein RAD

Names: RAD1; Ras-related associated with diabetes; ras associated with diabetes

NP_445790.2

EC 3.6.5.2

XP_006255117.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053338.2 → NP_445790.2 GTP-binding protein RAD

See identical proteins and their annotated locations for NP_445790.2

Status: VALIDATED

Source sequence(s)

CK602305, CK840773, FM054321, FM055705

UniProtKB/Swiss-Prot

P55043

UniProtKB/TrEMBL

A6JXU5, G3V7K9

Conserved Domains (2) summary

cd04148
Location:91 → 307

RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

smart00173
Location:91 → 251

RAS; Ras subfamily of RAS small GTPases