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    Ocln occludin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83497, updated on 2-Nov-2024

    Summary

    Official Symbol
    Oclnprovided by RGD
    Official Full Name
    occludinprovided by RGD
    Primary source
    RGD:620089
    See related
    EnsemblRapid:ENSRNOG00000071323 AllianceGenome:RGD:620089
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein domain specific binding activity. Involved in several processes, including cellular response to tumor necrosis factor; response to Gram-positive bacterium; and response to interleukin-18. Located in apical plasma membrane and lateral plasma membrane. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 177.7), Lung (RPKM 119.6) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ocln in Genome Data Viewer
    Location:
    2q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33391303..33442207, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31657217..31707466, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30527327..30577218, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NLR family, apoptosis inhibitory protein 6 Neighboring gene NLR family, apoptosis inhibitory protein 5 Neighboring gene general transcription factor IIH subunit 2 Neighboring gene ribosomal protein eL22-like 1 Neighboring gene uncharacterized LOC120100688 Neighboring gene RNA, U4 small nuclear 64

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood-brain barrier permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to interleukin-18 IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tight junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    occludin
    NP_112619.2
    XP_006231915.1
    XP_006231916.1
    XP_006231917.1
    XP_038959170.1
    XP_038959172.1
    XP_038959173.1
    XP_063138706.1
    XP_063138707.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031329.3NP_112619.2  occludin

      See identical proteins and their annotated locations for NP_112619.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q6P6T5, Q9Z303
      UniProtKB/TrEMBL
      A0A8L2QZI9, A6I594
      Related
      ENSRNOP00000098588.1, ENSRNOT00000121036.2
      Conserved Domains (2) summary
      pfam01284
      Location:57263
      MARVEL; Membrane-associating domain
      pfam07303
      Location:421520
      Occludin_ELL; Occludin homology domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      33391303..33442207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103242.2XP_038959170.1  occludin isoform X1

      UniProtKB/Swiss-Prot
      Q6P6T5, Q9Z303
      UniProtKB/TrEMBL
      A0A8L2QZI9, A6I594
      Conserved Domains (2) summary
      pfam01284
      Location:57263
      MARVEL; Membrane-associating domain
      pfam07303
      Location:421520
      Occludin_ELL; Occludin homology domain
    2. XM_063282637.1XP_063138707.1  occludin isoform X2

    3. XM_006231853.5XP_006231915.1  occludin isoform X1

      See identical proteins and their annotated locations for XP_006231915.1

      UniProtKB/Swiss-Prot
      Q6P6T5, Q9Z303
      UniProtKB/TrEMBL
      A0A8L2QZI9, A6I594
      Conserved Domains (2) summary
      pfam01284
      Location:57263
      MARVEL; Membrane-associating domain
      pfam07303
      Location:421520
      Occludin_ELL; Occludin homology domain
    4. XM_039103245.2XP_038959173.1  occludin isoform X2

      UniProtKB/TrEMBL
      A0A8L2QZI9
      Conserved Domains (2) summary
      pfam01284
      Location:57213
      MARVEL; Membrane-associating domain
      pfam07303
      Location:367466
      Occludin_ELL; Occludin homology domain
    5. XM_006231854.5XP_006231916.1  occludin isoform X1

      See identical proteins and their annotated locations for XP_006231916.1

      UniProtKB/Swiss-Prot
      Q6P6T5, Q9Z303
      UniProtKB/TrEMBL
      A0A8L2QZI9, A6I594
      Conserved Domains (2) summary
      pfam01284
      Location:57263
      MARVEL; Membrane-associating domain
      pfam07303
      Location:421520
      Occludin_ELL; Occludin homology domain
    6. XM_039103244.2XP_038959172.1  occludin isoform X1

      UniProtKB/Swiss-Prot
      Q6P6T5, Q9Z303
      UniProtKB/TrEMBL
      A0A8L2QZI9, A6I594
      Conserved Domains (2) summary
      pfam01284
      Location:57263
      MARVEL; Membrane-associating domain
      pfam07303
      Location:421520
      Occludin_ELL; Occludin homology domain
    7. XM_006231855.5XP_006231917.1  occludin isoform X1

      See identical proteins and their annotated locations for XP_006231917.1

      UniProtKB/Swiss-Prot
      Q6P6T5, Q9Z303
      UniProtKB/TrEMBL
      A0A8L2QZI9, A6I594
      Conserved Domains (2) summary
      pfam01284
      Location:57263
      MARVEL; Membrane-associating domain
      pfam07303
      Location:421520
      Occludin_ELL; Occludin homology domain
    8. XM_063282636.1XP_063138706.1  occludin isoform X1

      UniProtKB/Swiss-Prot
      Q6P6T5, Q9Z303
      UniProtKB/TrEMBL
      A6I594