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    Ptger2 prostaglandin E receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81752, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ptger2provided by RGD
    Official Full Name
    prostaglandin E receptor 2provided by RGD
    Primary source
    RGD:620020
    See related
    EnsemblRapid:ENSRNOG00000050968 AllianceGenome:RGD:620020
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    EP2; Ptger-ep2
    Summary
    Enables prostaglandin E receptor activity. Involved in positive regulation of gastric mucosal blood circulation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 19.1), Lung (RPKM 12.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptger2 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (20694765..20708475)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18215013..18228714)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19336029..19349759)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene Smad nuclear interacting protein 1, pseudogene 2 Neighboring gene uncharacterized LOC134482089 Neighboring gene uncharacterized LOC120096941 Neighboring gene uncharacterized LOC120096942 Neighboring gene ribosomal protein S10 like 6 Neighboring gene thioredoxin domain containing 16 Neighboring gene G protein-coupled receptor 137C Neighboring gene REST corepressor 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The localization of PGE2 receptor subtypes in rat retinal cultures and the neuroprotective effect of the EP2 agonist butaprost. Andrade da Costa BL, et al. Neurochem Int, 2009 Sep. PMID 19524109
    2. Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype. Nemoto K, et al. Prostaglandins, 1997 Oct. PMID 9440134
    3. Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor. Cherian PP, et al. J Biol Chem, 2003 Oct 31. PMID 12939279
    4. A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. Li M, et al. J Bone Miner Res, 2003 Nov. PMID 14606517
    5. Differential expression of prostaglandin E receptor subtype EP2 in rat uterus during early pregnancy. Shi JJ, et al. Histol Histopathol, 2005 Oct. PMID 16136483

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
      Title: Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP.
    2. Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
      Title: Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
    3. the involvement of prostaglandin signaling from mesenchymal stem cells in dopaminergic neuron survival through EP2 receptors, is reported.
      Title: Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons.
    4. EP2 contributes to generating mechanical hyperalgesia through positive feedback upregulation of COX-2 expression in muscle after lengthening contractions
      Title: EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions.
    5. These results indicate that EP2 activation, which initially promotes microglial activation, later causes delayed death of activated microglia, potentially contributing to the resolution phase of neuroinflammation.
      Title: EP2 Receptor Signaling Regulates Microglia Death.
    6. EP2/cAMP/protein kinase A pathway mediates the stimulatory effect of PGEs on angiogenesis essential for tissue injury healing via the induction of CREB activity and VEGF expression.
      Title: Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB.
    7. In the spinal cord 1 day after painful joint injury there is increased expression of prostaglandin E2 receptor.
      Title: Increased interleukin-1α and prostaglandin E2 expression in the spinal cord at 1 day after painful facet joint injury: evidence of early spinal inflammation.
    8. Elastogenesis is spatially regulated by PGE-EP4 signaling in the ductus arteriosus.
      Title: Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling.
    9. Data indicate that painful cervical facet joint distraction induces an immediate and sustained increase of prostaglandin E2 (PGE2) receptor EP2 expression in the dorsal root ganglion (DRG).
      Title: The prostaglandin E2 receptor, EP2, is upregulated in the dorsal root ganglion after painful cervical facet joint injury in the rat.
    10. EP2 receptor signaling pathways regulate classical activation of microglia
      Title: EP2 receptor signaling pathways regulate classical activation of microglia.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prostaglandin E receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prostaglandin E receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to prostaglandin E stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to prostaglandin E stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gastric mucosal blood circulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to nematode ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to progesterone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin E2 receptor EP2 subtype
    Names
    PGE receptor, EP2 subtype
    PGE2 receptor EP2 subtype
    prostaglandin E receptor 2 (subtype EP2)
    prostaglandin E receptor EP2 subtype
    prostaglandin E2 receptor EP2 subtype-like
    prostaglandin E2 receptor type 2
    prostanoid EP2 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031088.2 → NP_112350.1  prostaglandin E2 receptor EP2 subtype

      See identical proteins and their annotated locations for NP_112350.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q547S0, Q62928
      UniProtKB/TrEMBL
      A6KDY9
      Related
      ENSRNOP00000064907.1, ENSRNOT00000075209.4
      Conserved Domains (1) summary
      pfam00001
      Location:39 → 314
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      20694765..20708475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093687.2 → XP_038949615.1  prostaglandin E2 receptor EP2 subtype isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:24 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:24 → 281
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. XR_001841264.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62928.1 GenPept UniProtKB/Swiss-Prot:Q62928

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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