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    Nfkbib NFKB inhibitor beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81525, updated on 2-Nov-2024

    Summary

    Official Symbol
    Nfkbibprovided by RGD
    Official Full Name
    NFKB inhibitor betaprovided by RGD
    Primary source
    RGD:621887
    See related
    EnsemblRapid:ENSRNOG00000020063 AllianceGenome:RGD:621887
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NF-kappaB binding activity. Involved in cytoplasmic sequestering of NF-kappaB. Predicted to be located in cytoplasm and nucleus. Predicted to be part of I-kappaB/NF-kappaB complex. Orthologous to human NFKBIB (NFKB inhibitor beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 86.7), Adrenal (RPKM 58.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nfkbib in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93173817..93181387, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84046292..84053862, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (86941073..86948845, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene sirtuin 2 Neighboring gene Ras and Rab interactor-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General protein information

    Preferred Names
    NF-kappa-B inhibitor beta
    Names
    I-kappa-B-beta
    NF-kappa-BIB
    ikB-B
    ikB-beta
    ikappaBbeta
    nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta
    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030867.2NP_110494.2  NF-kappa-B inhibitor beta

      See identical proteins and their annotated locations for NP_110494.2

      Status: PROVISIONAL

      Source sequence(s)
      BC085729
      UniProtKB/Swiss-Prot
      Q9JIA3
      UniProtKB/TrEMBL
      Q5U342
      Related
      ENSRNOP00000086277.2, ENSRNOT00000098249.2
      Conserved Domains (3) summary
      PHA03095
      Location:203298
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:57148
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:206237
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93173817..93181387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)