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    RAB11FIP1 RAB11 family interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 80223, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RAB11FIP1provided by HGNC
    Official Full Name
    RAB11 family interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:30265
    See related
    Ensembl:ENSG00000156675 MIM:608737; AllianceGenome:HGNC:30265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RCP; NOEL1A; rab11-FIP1
    Summary
    This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
    Expression
    Broad expression in lung (RPKM 41.1), small intestine (RPKM 24.3) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RAB11FIP1 in Genome Data Viewer
    Location:
    8p11.23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (37858618..37899497, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (38135023..38175900, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37716136..37757015, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37645266-37645774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37652831-37653396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37653397-37653962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27233 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37667034-37667256 Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37671601-37672366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37672367-37673132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37673133-37673898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37679325-37679898 Neighboring gene VISTA enhancer hs1665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37685664-37686632 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37696873-37697010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37699228-37699928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27234 Neighboring gene BRF2 general transcription factor IIIB subunit Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37737517-37738231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37738232-37738945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27237 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37747172-37748110 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37748111-37749049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19111 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37754638-37755270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37767897-37768396 Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37773378-37773893 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37773894-37774410 Neighboring gene Sharpr-MPRA regulatory region 5273 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37792805-37793306 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:37797148-37797664 Neighboring gene glutamic-oxaloacetic transaminase 1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking. Campa CC, et al. Adv Biol Regul, 2017 Jan. PMID 27658318
    2. Rab11 is phosphorylated by classical and novel protein kinase C isoenzymes upon sustained phorbol ester activation. Pavarotti M, et al. Biol Cell, 2012 Feb. PMID 22188018
    3. Rab11-FIP1A regulates early trafficking into the recycling endosomes. Schafer JC, et al. Exp Cell Res, 2016 Jan 15. PMID 26790954, Free PMC Article
    4. RCP is a human breast cancer-promoting gene with Ras-activating function. Zhang J, et al. J Clin Invest, 2009 Aug. PMID 19620787, Free PMC Article
    5. Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. Caswell PT, et al. J Cell Biol, 2008 Oct 6. PMID 18838556, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin beta1 recycling on the membrane.
      Title: microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane.
    2. Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4[+] T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines.
      Title: Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4(+) T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines.
    3. Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.
      Title: Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.
    4. Thrombin-activated PAR1 membrane expression is regulated by Rab11a-RCP complex dissociation.
      Title: Thrombin-activated PAR1 membrane expression is regulated by Rab11a-RCP complex dissociation.
    5. Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission.
      Title: Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission.
    6. Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol.
      Title: Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol.
    7. Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90alpha Secretion.
      Title: Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.
    8. The findings thus define that delivery of recycling cargo toward the ERC requires spatial and sequential coupling of Rab11 activity with PtdIns(3)P turnover.
      Title: Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes.
    9. Phosphorylation of RCP at Ser(435) by Lemur tyrosine kinase-3 (LMTK3) and of EphA2 at Ser(897) by Akt are both necessary to promote Rab14-dependent (and Rab11-independent) trafficking of EphA2 which generates cell:cell repulsion events that drive tumour cells apart.
      Title: Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
    10. The article focuses on the latest advances regarding the mechanisms that ensure the compartmentalized regulation of Rab11 function through its interaction with phosphoinositides. (Review)
      Title: Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of RAB11-FIP1C by shRNA inhibits HIV-1 infectivity in TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed
    env RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env relocalizes FIP1C to plasma membrane in a cytoplasmic tail-dependent manner PubMed
    env RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions PubMed
    Envelope transmembrane glycoprotein gp41 env Second-site reversion mutation in theHIV-1 gp41 cytoplasmic tail is required to restore HIV-1 Env incorporation in YW795SL gp41 mutant in all cell types PubMed
    env The YW795 motif in the HIV-1 gp41 cytoplasmic tail is required for efficient cell-to-cell spread in nonpermissive cells PubMed
    env The YW795 motif in the HIV-1 gp41 cytoplasmic tail is required for HIV-1 Env-mediated redistribution of RAB11FIP1 and for Env incorporation in to virions PubMed
    env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed
    env RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22524, FLJ22622, MGC78448, DKFZp686E2214

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of adiponectin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rab11 family-interacting protein 1
    Names
    RAB11 coupling protein
    RAB11 family interacting protein 1 (class I)
    Rab effector protein
    Rab-interacting recycling protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002814.3 → NP_001002814.2  rab11 family-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001002814.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
      Source sequence(s)
      AC130304, AK026275, AY280968, BC077720
      Consensus CDS
      CCDS34882.1
      UniProtKB/Swiss-Prot
      J3KNP0, Q307T1, Q6AZK4, Q6WKZ2, Q6WKZ4, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642
      Related
      ENSP00000331342.4, ENST00000330843.9
      Conserved Domains (2) summary
      cd08682
      Location:20 → 147
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:1226 → 1273
      RBD-FIP; FIP domain

    2. NM_025151.5 → NP_079427.4  rab11 family-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_079427.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. It encodes isoform 1, which is shorter than isoform 3.
      Source sequence(s)
      AC130304, AK026275, BC077720
      Consensus CDS
      CCDS34881.1
      UniProtKB/Swiss-Prot
      Q6WKZ4
      Related
      ENSP00000287263.4, ENST00000287263.8
      Conserved Domains (2) summary
      cd08682
      Location:20 → 147
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:592 → 639
      RBD-FIP; FIP domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      37858618..37899497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013869.2 → XP_016869358.1  rab11 family-interacting protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      38135023..38175900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361288.1 → XP_054217263.1  rab11 family-interacting protein 1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002233.1: Suppressed sequence

      Description
      NM_001002233.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support an internal transcription initiation site.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6WKZ4.3 GenPept UniProtKB/Swiss-Prot:Q6WKZ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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